Find an abstract and a link to most of the publications produced by Nordic Bioscience
Type XI collagen has been associated with tumor fibrosis and aggressiveness in patients with pancreatic ductal adenocarcinoma (PDAC). The propeptide on Type XI collagen is released into the circulation after proteolytic processing at either amino acid 253 or 511. This allows for a noninvasive biomar...
July 1, 2021
Journal:
Int J Cancer
Author:
Nissen NI, Johansen AZ, Chen IM, Karsdal MA, Diab HMH, Jørgensen LN, Sun S, Manon-Jensen T, He Y, Willumsen N, Johansen JS, Kehlet SN, Langholm LL
A desmoplastic colorectal cancer stroma, characterized by excess turnover of the cancer-associated fibroblast derived collagens type III and VI, can lead to reduced drug-uptake and poor treatment response. We investigated the association between biomarkers of collagen type III and VI and overall sur...
January 19, 2021
Journal:
Sci Rep
Author:
Nissen NI, Boisen MK, Liljefors M, Jensen C, Johansen AZ, Johansen JS, Erler JT, Mortensen JH, Høye A, Willumsen N, Karsdal MA, Kehlet SN
Background: Inguinal hernia disease is associated with an imbalanced collagen metabolism. Surgical stress has a negative impact on nutrients important for collagen synthesis. Objective: We hypothesized that supplementation with a combination of nutrients would enhance collagen biosynthesis in ingui...
January 3, 2020
Journal:
J Nutr
Author:
Kjaer M, Frederiksen AKS, Nissen NI, Willumsen N, Van Hall G, Jorgensen LN, Andersen JR, Årgen MS
Introduction: Vimentin has shown to be highly implicated in cancer initiation and progression. Vimentin is often a target of post-translational modifications (PTMs) which can be disease specific, thus targeting these specific modifications can be of high biomarker potential. In this study we set out...
The extracellular matrix (ECM) plays an important role in cancer progression. It can be divided into the basement membrane (BM) that supports epithelial/endothelial cell behavior and the interstitial matrix (IM) that supports the underlying stromal compartment. The major components of the ECM are th...
March 6, 2019
Journal:
Journal of Experimental Clinical Cancer Research
Author:
Karsdal MA, Willumsen N, Nissen NI
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