Biomarker name
Assay description
Function

PRO-C8
A fragment of C-terminal type VIII collagen
Signaling peptide of the basement membrane, ECM formation
AGR-N
N-terminal of agrin
Basement membrane degradation
ARGS
N-terminal epitope of aggrecanase mediated degradation of aggrecan
Cartilage remodeling
Arresten
Signaling fragment of type IV collagen alpha 1
Signaling peptide of the basement membrane
BGM
Neo-epitope of MMP-9,12 mediated degradation of biglycan
Pericellular matrix (proteoglycan) degradation
BREM
Brevican degraded by MMPs
Brain tissue remodeling
BREV-A
Neo-epitope of ADAMTS-4 mediated degradation of brevican
Brain tissue remodeling
C3A
Neo-epitope of ADAMTS-4,5 mediated degradation of type III collagen
Degradation of interstitial matrix and remodeling
C3C
Neo-epitope of cathepsin-B,L,S mediated degradation of type III collagen
Degradation of interstitial matrix and remodeling
C4Ma1
MMP-degradation fragment of type IVa1 collagen chain
Basement membrane degradation and remodeling
C4Ma3
Neo-epitope of MMP-2,9,12 mediated degradation of type IV collagen alpha 3 chain
Basement membrane degradation
C5CM
Neo-epitope of MMP mediated degradation of citrullinated type V collagen
N/A
C6A6
A fragment of C-terminal type VIa6 collagen
ECM turnover
C6Ma1
Neo-epitope of MMP-2 mediated degradation of type VIa1 collagen
Connective tissue degradation
C6Ma3
Neo-epitope of MMP-9 mediated degradation of type VI collagen
Interface matrix degradation
CHPRO-C2
Released N-terminal pro-peptide of type II collagen for explant use
Formation of type II (cartilage collagen) in explants
COMP C3a desARG
Specific fragment of carboxypeptidase-mediated degradation of anaphylatoxin C3a
N/A
COMP-C5a
N-terminal anaphylatoxin C5a
Complement activation
COMP-N
N-terminal of COMP
N/A
CRPM
Neo-epitope of MMP-mediated degradation c-reactive protein
Tissue inflammation
DCN-CS
Cathepsin S mediated decorin degradation
Pericellular matrix (proteoglycan) degradation
EL-CG
Neo-epitope of cathepsin G mediated degradation of elastin
ECM remodeling
EL-NE
Neo-epitope of neutrophil elastase mediated degradation of elastin
ECM remodeling
EL-SIG
Signal peptide of elastin
N/A
ELM
Neo-epitope ('441) of MMP-9,12 mediated degradation of elastin
Stromal reactivity

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