Biomarker name
Assay description
Biomarker meaning
a-SMA
Acetylated N-terminal of alpha-smooth muscle actin
Fibroblast activity
C10C
Neo Epitope of cathepsin-K mediated degradation of type X collagen
Endochondral bone remodeling
C1M
MMP-degradation fragment of type I collagen 
Inflammation driven degradation
C2M
Neo-epitope of MMP mediated degradation of type II collagen
Degradation of cartilage matrix
C3M
Neo-epitope of MMP-9 mediated degradation of type III collagen
Degradation of interstitial matrix and remodeling
C4G
Neo-epitope of granzyme B mediated degradation of type IV collagen
T-cell activity
C4M
Neo-epitope of MMP-2,9,12 mediated degradation of type IV collagen alpha 1 chain
Basement membrane degradation
C5M
Neo-epitope of MMP-2,9 mediated degradation of type V collagen
Degradation of interstitial matrix and remodeling
C6M
Neo-epitope of MMP-2 mediated degradation of type VI collagen
Interface matrix degradation
C7M
Neo-epitope of type MMP-13 mediated degradation of type VII collagen
Degradation of anchoring fibrils
COL10NC
A chemiluminescence sandwich assay measuring the NC1 domain of type X collagen
Not available
CPa9-HNE
Neo-epitope of human neutrophil elastase (HNE) mediated degradation of calprotectin
Neutrophil activity
CTX-I
Neo-epitope of cathepsin mediated degradation of type I collagen
Bone resorption
CTX-II
Neo-epitope of MMP mediated degradation of type II collagen
Cartilage Degradation
CTX-III
Cross-linked type III collagen C-terminal telopeptide
Fibrosis resolution
PRO-C1
Internal epitope in the N-terminal pro-peptide of type I collagen
Bone formation
PRO-C11
Released N-terminal pro-peptide of type XI collagen
Fibrogenesis
PRO-C19
C-terminal of type XIX collagen
Basement membrane degradation and remodeling
PRO-C2
Released N-terminal pro-peptide of type II collagen
Formation of cartilage
PRO-C4
Internal epitope in the 7S domain of type IV collagen
Basement membrane synthesis
PRO-C5
Released C-terminal pro-peptide of type V collagen
Basement membrane degradation and remodeling
PRO-C6
C-terminal of released C5 domain of type VI collagen α3 chain (endotrophin)
Pro-fibrotic signaling
PRO-C8
C-terminal of type XVIII collagen, NC1 domain
Signaling peptide of the basement membrane
TUM
MMP-9 mediated release of tumstatin from type IV collagen alpha 3 chain
Signaling peptide of the basement membrane
VICM
Neo- epitope of MMP-2, 8 and trypsin mediated degradation of citrullinated vimentin
Macrophage activity
AGR-N
N-terminal of agrin
Basement membrane degradation
ARGS
N-terminal epitope of aggrecanase mediated degradation of aggrecan
Cartilage remodeling
Arresten
Signaling fragment of type IV collagen alpha 1
Signaling peptide of the basement membrane
BGM
Neo-epitope of MMP-9,12 mediated degradation of biglycan
Pericellular matrix (proteoglycan) degradation
BREM
Brevican degraded by MMPs
Brain tissue remodeling
BREV-A
Neo-epitope of ADAMTS-4 mediated degradation of brevican
Brain tissue remodeling
C2M_HP
Neo-epitope of MMP mediated degradation of type II collagen
Degradation of cartilage matrix
C3A
Neo-epitope of ADAMTS-4,5 mediated degradation of type III collagen
Degradation of interstitial matrix and remodeling
C3C
Neo-epitope of cathepsin-B,L,S mediated degradation of type III collagen
Degradation of interstitial matrix and remodeling
C3M_HP
Neo-epitope of MMP-9 mediated degradation of type III collagen
Degradation of interstitial matrix and remodeling
C4G_HP
Neo-epitope of granzyme B mediated degradation of type IV collagen High Precision (i10)
T-cell activity
C4Ma1
MMP-degradation fragment of type IVa1 collagen chain
Basement membrane degradation and remodeling
C4Ma3
Neo-epitope of MMP-2,9,12 mediated degradation of type IV collagen alpha 3 chain
Basement membrane degradation
C5CM
Neo-epitope of MMP mediated degradation of citrullinated type V collagen
Not available
C6Ma1
Neo-epitope of MMP-2 mediated degradation of type VIa1 collagen
Connective tissue degradation
C6Ma3
Neo-epitope of MMP-9 mediated degradation of type VI collagen
Interface matrix degradation
CHPRO-C2
Released N-terminal pro-peptide of type II collagen for explant use
Formation of type II (cartilage collagen) in explants
COL10NC_HP
A chemiluminescence sandwich assay measuring the NC1 domain of type X collagen
Not available
COMP C3a desARG
Specific fragment of carboxypeptidase-mediated degradation of anaphylatoxin C3a
Not available
COMP-C5a
N-terminal anaphylatoxin C5a
Complement activation
COMP-N
N-terminal of COMP
Not available
CRPM
Neo-epitope of MMP-mediated degradation c-reactive protein
Tissue inflammation
cyARGS
N-terminal epitope of aggrecanase mediated degradation of aggrecan in cynomolgus
Cartilage remodeling
DCN-CS
Cathepsin S mediated decorin degradation
Pericellular matrix (proteoglycan) degradation

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