Publications
Find an abstract and a link to most of the publications produced by Nordic Bioscience
Background and aims: Liver fibrosis results from a prolonged wound healing response to continued injury with excessive production of extracellular proteins. In patients with chronic liver disease, the monitoring of liver fibrosis dynamics is of high interest. Whilst markers of fibrogenesis exist, ...
April 12, 2022
Journal:
Liver Int
Author:
Pehrsson M, Manon-Jensen T, Sun S, Villesen IF, Castane H, Joven J, Patel K, Goodman Z, Bay-Jensen AC, Mortensen JH, Karsdal MA, Leeming DJ, Nielsen MJ
Increased turnover of extracellular matrix proteins is seen in many different diseases and is an underlying and driving feature of pathogenesis. An increased ratio of formation over degradation of extracellular matrix proteins, such as collagens, leads to accumulation of proteins in the tissues, ult...
September 10, 2021
Journal:
J Pharm Biomed Anal.
Author:
Reese-Petersen AL, Willumsen N, Palau P, Nunez J, Sun S, Manon-Jensen T, Kamall B, Karsdal MA, Genovese F
Type XI collagen has been associated with tumor fibrosis and aggressiveness in patients with pancreatic ductal adenocarcinoma (PDAC). The propeptide on Type XI collagen is released into the circulation after proteolytic processing at either amino acid 253 or 511. This allows for a noninvasive biomar...
July 1, 2021
Journal:
Int J Cancer
Author:
Nissen NI, Johansen AZ, Chen IM, Karsdal MA, Diab HMH, Jørgensen LN, Sun S, Manon-Jensen T, He Y, Willumsen N, Johansen JS, Kehlet SN, Langholm LL
Osteogenesis imperfecta (OI), a heritable disorder caused by abnormalities in synthesis or processing of type I collagen, is characterized by skeletal fragility. Type I collagen interacts with multiple components of the extracellular matrix (ECM) including other collagens types. Thus, alterations in...
January 4, 2021
Journal:
Bone
Author:
Nicol L, Srikanth P, Henriksen K, Sun S, Smith R, Karsdal MA, Nagamani SCS, Shapiro J, Lee B, Leder BZ, Orwoll E
BACKGROUND AND AIMS: Crohns disease (CD) is a chronic inflammatory condition characterized by continuous mucosal damage and ongoing wound healing of the intestines. The fibrinolytic system is involved in early parts of the wound healing process. Fibrin is a key mediator of primary blood clot formati...
June 1, 2019
Journal:
J Gastrointestin Liver Dis
Author:
Sun S, Karsdal MA, Mortensen JH, Luo Y, Kjeldsen J, Krag A, Jensen MD, Bay-Jensen AC, Manon-Jensen T
BACKGROUND: Biomarkers that predict response to anabolic therapies could expedite the development of function promoting anabolic drugs. This study aimed to identify serum biomarkers that are responsive to testosterone administration and associated with increases in fat-free mass (FFM). METHODS: Ser...
May 23, 2019
Journal:
J Clin Endocrinol Metab
Author:
Huang G, Rocha GV, Pencina KM, Cox K, Krishnan V, Henriksen K, Sissons SE, Li Z, Nedergaard AF, Karsdal MA, Sun S, Storer TW, Basaria S, Bhasin S, Mitchell PG
Background: Crohn’s disease (CD) is a chronic inflammatory condition of the intestinal tract resulting in severe intestinal tissue damage. The concept of mucosal healing has therefore gained significant interest as a therapeutic end point in the treatment of inflammatory bowel disease (IBD). Given t...
January 31, 2019
Journal:
EC Gastroenterology and Digestive
Author:
Manon-Jensen T, Langholm LL, Sun S, Mortensen JH, He Y, Krag A, Jensen MD, Bay-Jensen AC, Kjeldsen J, Karsdal MA
Osteogenesis imperfecta (OI) is a rare disorder of connective tissue caused by abnormalities in the synthesis or processing of type I collagen. Type I collagen is the most abundant type of collagen and is expressed in almost all connective tissues. Given that type I collagen interacts with other col...
October 2, 2018
Journal:
Bone
Author:
Nicol L, Morar P, Wang Y, Henriksen K, Sun S, Karsdal MA, Smith R, Nagamani SCS, Shapiro J, Lee B, Orwoll E
Chronic obstructive pulmonary disease (COPD) is characterized by high levels of protease activity leading to degradation of elastin followed by loss of elasticity of the lung and the development of emphysema. Elastin is an essential structural component of the lung parenchyma to support the expansio...
September 10, 2018
Journal:
Biochem Biophys Res Commun
Author:
Gudmann NS, Manon-Jensen T, Diefenbach C, Sun S, Danielsen A, Karsdal MA, Leeming DJ, Bülow Sand JM
The matricellular protein SPARC (secreted proteome acidic and rich in cysteine) is known to bind collagens and regulate fibrillogenesis. Cleavage of SPARC at a single peptide bond, increases the affinity for collagens up to 20-fold. To investigate if this specific cleavage has pathological relevance...
August 1, 2018
Journal:
Cancer biology therapy
Author:
Kehlet SN, Manon-Jensen T, Sun S, Brix S, Karsdal MA, Leeming DJ, Willumsen N
OBJECTIVES: Fibrosis and cancer are characterized by extracellular matrix (ECM) remodeling. The basement membrane is mainly composed by collagen type IV and laminin. Tumstatin is a matrix metalloproteinase-9 (MMP-9) generated matrikine of collagen type IV α3 chain. We evaluated the potential of tums...
March 7, 2018
Journal:
Transl Oncol
Author:
Nielsen SH, Willumsen N, Brix S, Sun S, Manon-Jensen T, Karsdal MA, Genovese F
INTRODUCTION: The medical need in the haemophilic (HF) field to reduce bleeding incidents requires measurement of the annual bleeding rate (ABR) in haemophiliacs. Vascular rupture is associated with damage to the vascular endothelium causing exposure of the basement membrane. Endothelial cells and m...
Altered extracellular matrix (ECM) turnover is a central pathological feature of many diseases. The ECM is a meshwork of molecules that provides structural support to cells throughout the body. It consists mainly of two membranes: the interstitial matrix, which is present between parenchymal cells i...
August 29, 2017
Journal:
Haemophilia
Author:
Manon-Jensen T, Hua BL, Olsen EHN, Sun S, Gudme CN, Li J, Lei W, Vandahl B, Roepstorff K, Kjelgaard-Hansen M, Zhao Y, Karsdal MA
OBJECTIVE: Biologics for rheumatoid arthritis (RA) patients with moderate to severe disease may preserve joint function. Matrix metalloproteinase 3 (MMP-3), a key tissue degrading protease, is highly elevated in RA. MMP-3, which measures the total pool of circulating MMP-3 species (cMMP3), is a comm...
August 28, 2017
Journal:
Clin Exp Rheumatol
Author:
Siebuhr AS, Kjelgaard-Petersen CF, Sun S, Byrjalsen I, Christiansen C, Karsdal MA, Bay-Jensen AC
Introduction: Progressive arthropathy caused by recurrent joint bleeds is a severe complication in haemophilia. Aim: We investigated whether biomarkers of cartilage and bone degradation, and inflammation were altered in haemophilia patients and whether these biomarkers could identify haemophilia pa...
April 24, 2017
Journal:
Haemophilia
Author:
Olsen EHN, Sun S, Gudme CN, Wang L, Vandahl B, Roepstorff K, Kjelgaard-Hansen M, Sørensen BB, Zhao Y, Karsdal MA, Manon-Jensen T, Hua BL
BACKGROUND:Muscle mass and function are perturbed by immobilization and remobilization. When muscle mass changes, the quality and quantity of the extracellular matrix protein, particularly the collagens, change with it. In this study, we investigated the temporal profile of three peptide biomarkers ...
December 7, 2015
Journal:
PLoS One
Author:
Sun S, Henriksen K, Karsdal MA, Byrjalsen I, Rittweger J, Armbrecht G, Belavý DL, Nedergaard AF, Felsenberg D
Background: Exacerbations of chronic obstructive pulmonary disease (COPD) contribute significantly to disease progression. However, the effect on tissue structure and turnover is not well described. There is an urgent clinical need for biomarkers of disease activity associated with disease progressi...
June 11, 2015
Journal:
Respir Res.
Author:
Knox AJ, Lange P, Sun S, Kristensen JH, Leeming DJ, Karsdal MA, Bolton CE, Johnson SR, Bülow Sand JM
Purpose: In this study we sought to determine whether a Titin peptide fragment can serve as a clinical biomarker for changes in muscle mass. Methods: Mass spectrometry was used to identify Titin fragment in urine. An antibody against this Titin sequence was raised and used to develop a competitive ...
October 9, 2014
Journal:
Exp Gerontol
Author:
Sun S, Henriksen K, Armbrecht G, Belavý DL, Felsenberg D, Rittweger J, Wang Y, Zheng Q, Nedergaard AF, Karsdal MA
Background: Matrix metalloproteinase-3 (MMP-3) plays an important role in the pathology of rheumatoid arthritis (RA) and ankylosing spondylitis (AS). Measurement of active MMP-3 in clinical samples could provide information about progression of rheumatoid diseases, and potentially response to treatm...
March 19, 2014
Journal:
BMC Musculoskelet Disord.
Author:
Sun S, Bay-Jensen AC", "Karsdal MA", "Siebuhr AS", "Zheng Q", "Maksymowych WP", "Christiansen TG", "Henriksen K"
Immobilization-induced loss of muscle mass is a complex phenomenon with several parallels to sarcopenic and cachectic muscle loss. Muscle is a large organ with a protein turnover that is orders of magnitude larger than most other tissues. Thus, we hypothesize that muscle loss and regain is reflected...
December 12, 2013
Journal:
J Cachexia Sarcopenia Muscle
Author:
Sun S, Karsdal MA, Henriksen K, Nedergaard AF
Objective: Cathepsin K plays essential roles in bone resorption and is intensely investigated as a therapeutic target for the treatment of osteoporosis. Hence an assessment of the active form of cathepsin K may provide important biological information in metabolic bone diseases, such as osteoporos...
October 6, 2013
Journal:
Clin Biochem
Author:
Sun S, Karsdal MA, Bay-Jensen AC, Sørensen MG, Zheng Q, Dziegiel MH, Maksymowych WP, Henriksen K
Extracellular matrix remodelling is a prerequisite for plaque rupture in atherosclerotic lesion. Versican, an extracellular matrix proteoglycan present in normal and atherosclerotic arteries is a substrate for matrix metalloproteinases (MMPs) present in macrophage rich areas. The aim of the current ...
June 3, 2013
Journal:
Int J Clin Exp Med.
Author:
Barascuk N, Genovese F, Larsen L, Byrjalsen I, Zheng Q, Sun S, Hosbond S, Poulsen TS, Jensen JM, Mickley H, Register TC, Rasmussen LM, Leeming DJ, Christiansen C, Karsdal MA, Diederichsen ACP
The present study describes the assessment of true formation of type III collagen in different pathologies using a neo-epitope specific competitive Enzyme-linked immunosorbent assay (ELISA) towards the N-terminal propeptide of type III collagen (PRO-C3). METHODS The monoclonal antibody was raised ...
April 19, 2013
Journal:
Am J Transl Res
Author:
Nedergaard AF, Sun S, Veidal SS, Larsen L, Zheng Q, Suetta C, Henriksen K, Christiansen C, Karsdal MA, Leeming DJ, Nielsen Frost M
Objectives: Type V collagen has been demonstrated to control fibril formation. The aim of this study was to develop an ELISA capable of detecting a fragment of type V collagen generated by MMP-2/9 and to evaluate the assay as biomarker for ankylosing spondylitis (AS). Design and methods: A fragment ...
May 7, 2012
Journal:
Clin Biochem.
Author:
Veidal SS, Larsen DV, Chen X, Sun S, Zheng Q, Bay-Jensen AC, Leeming DJ, Nawrocki A, Larsen MR, Schett G, Karsdal MA
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