Publications
Find an abstract and a link to most of the publications produced by Nordic Bioscience
BACKGROUND Endotrophin, a collagen type VI–derived peptide, mediates metabolic dysregulation, inflammation, and fibrosis in animal models, but has not been studied in human heart failure (HF). METHODS We examined the association between circulating endotrophin and outcomes in participants sufferi...
September 21, 2022
Journal:
NEJM Evidence
Author:
Chirinos JA, Zhao L, Reese-Petersen AL, Cohen JB, Genovese F, Richards AM, Doughty RN, Diez J, Gonzalez A, Querejeta R, Zamani P, Nunez J, Wang Z, Ebert C, Kammerhoff K, Maranville J, Basso M, Qian C, Rasmussen DKG, Schafer PH, Seiffert D, Karsdal MA, Gordon DA, Ramirez-Valle F, Cappola TP
Background Aberrant extracellular matrix (ECM) deposition and remodelling is important in the disease pathogenesis of pulmonary fibrosis (PF). We characterised neoepitope biomarkers released by ECM turnover in lung tissue from bleomycin-treated rats and patients with PF and analysed the effects of ...
August 4, 2022
Journal:
Respiratory Research
Author:
Hesse C, Beneke V, Konzok S, Diefenbach C, Bülow Sand JM, Rønnow S, Karsdal MA, Jonigk D, Sewald K, Braun A, Leeming DJ, Wollin L
Background and aims: Liver fibrosis results from a prolonged wound healing response to continued injury with excessive production of extracellular proteins. In patients with chronic liver disease, the monitoring of liver fibrosis dynamics is of high interest. Whilst markers of fibrogenesis exist, ...
April 12, 2022
Journal:
Liver Int
Author:
Pehrsson M, Manon-Jensen T, Sun S, Villesen IF, Castane H, Joven J, Patel K, Goodman Z, Bay-Jensen AC, Mortensen JH, Karsdal MA, Leeming DJ, Nielsen MJ
Background and aims Endoscopy and the use of fecal calprotectin (fecal CP) are among the least favored methods for assessing disease activity by inflammatory bowel disease (IBD) patients; the handling/processing of fecal samples is also impractical. Therefore, we sought to develop a novel neo-epi...
March 19, 2022
Journal:
Journal of Crohn's and Colitis
Author:
Mortensen JH, Sinkeviciute D, Manon-Jensen T, Domislovic V, McCall K, Thudium CS, Brinar M, Önnerfjord P, Goodyear CS, Krznaric Z, Karsdal MA, Bay-Jensen AC
Background: Extensive extracellular matrix (ECM) remodeling is a hallmark of metastatic pancreatic ductal adenocarcinoma (mPDA). We investigated fragments of collagen types III (C3M, PRO-C3), VI (PRO-C6), and VIII (C8-C), and versican (VCANM) in plasma as biomarkers for predicting progression-free s...
September 27, 2021
Journal:
J Transl Med.
Author:
Wang S, Bager CL, Karsdal MA, Chondros D, Taverna D, Willumsen N
Background: Osteoarthritis (OA) is a disease with multiple endotypes. A hallmark of OA is loss of cartilage; however, it is evident that the rate of cartilage loss differs among patients, which may partly be attributed to differential capacity for cartilage repair. We hypothesize that a low cartilag...
September 24, 2021
Journal:
J Orthop Traumatol
Author:
Luo Y, Samuels J, Krasnokutsky S, Byrjalsen I, Kraus VB, He Y, Karsdal MA, Abramson SB, Attur M, Bay-Jensen AC
Objective: The purpose of this overview of osteoarthritis (OA) biomarkers is to provide the non-specialist with a toolbox, based on experience acquired by biomarker researchers over many years, to understand biomarkers in general and their use in the OA field. Methods: We provide an update on this ...
Increased turnover of extracellular matrix proteins is seen in many different diseases and is an underlying and driving feature of pathogenesis. An increased ratio of formation over degradation of extracellular matrix proteins, such as collagens, leads to accumulation of proteins in the tissues, ult...
September 10, 2021
Journal:
J Pharm Biomed Anal.
Author:
Reese-Petersen AL, Willumsen N, Palau P, Nunez J, Sun S, Manon-Jensen T, Kamall B, Karsdal MA, Genovese F
Objective: To compare C-reactive protein (CRP) and matrix metalloproteinase-generated neoepitope of CRP (CRPM) as biomarkers of inflammation and radiographic severity in patients with knee osteoarthritis. Methods: Participants with symptomatic osteoarthritis (n=25) of at least one knee underwent kn...
August 31, 2021
Journal:
Arthritis Res Ther
Author:
Jr Alexander LC, McHorse G, Huebner JL, Bay-Jensen AC, Karsdal MA, Kraus VB
Background & aims: Non-alcoholic fatty liver disease (NAFLD) is a common liver disorder with non-alcoholic steatohepatitis (NASH) being a more progressive phenotype associated with progression to cirrhosis. Type III collagen is a main component of the fibrotic extracellular matrix. PRO-C3 is a b...
August 26, 2021
Journal:
J Hepatol
Author:
Leeming DJ, Goodman Z, Friedman S, Frederiksen P, Vig P, Seyedkazemi S, Fischer L, Torstenson R, Karsdal MA, Lefebvre E, Sanyal JA, Ratziu V, Nielsen MJ
Objectives: There is a need for precision medicine and an unspoken promise of an optimal approach for identification of the right patients for value-based medicine based on big data. However, there may be a misconception that measurement of proteins is more valuable than measurement of fewer selecte...
August 26, 2021
Journal:
Clin Biochem
Author:
Karsdal MA, Rasmussen DGK, Bay-Jensen AC, Mortensen JH, Holm Nielsen S, Willumsen N, Jensen C, Manon-Jensen T, Jennings L, Reese-Petersen AL, Henriksen K, Leeming DJ, Bager CL, Genovese F, Bülow Sand JM
Background: Liver fibrosis accumulation is considered a turnover disease, with formation exceeding degradation, although this hypothesis has never been tested in humans. Aims: To investigate extracellular matrix (ECM) remodelling in a biopsy-controlled study of alcohol-related liver disease (ALD) p...
August 24, 2021
Journal:
Aliment Pharmacol Ther.
Author:
Thiele M, Johansen S, Gudmann NS, Kjaergaard M, Leeming DJ, Jacobsen S, Bendtsen F, Møller S, Detlefsen S, Karsdal MA, Krag A, Madsen BS, Nielsen MJ
Introduction: Enzymatic cross-linking of the collagens within the extracellular matrix (ECM) catalyzed by enzymes such as lysyl oxidase (LOX) and lysyl oxidase like-enzymes 1-4 (LOXL), transglutaminase 2 (TG2), and peroxidasin (PXDN) contribute to fibrosis progression through extensive collagen cros...
August 24, 2021
Journal:
Expert Rev Mol Diagn
Author:
Pehrsson M, Mortensen JH, Manon-Jensen T, Bay-Jensen AC, Karsdal MA, Davies MJ
Objective: To investigate acute changes in biochemical markers of cartilage turnover in response to moderate intensity exercise with and without joint impact in humans with knee osteoarthritis. Design: We conducted a randomized, cross-over, exploratory clinical study. Twenty subjects with knee osteo...
July 29, 2021
Journal:
Osteoarthritis Cartilage
Author:
Bjerre-Bastos JJ, Andersen JR, Karsdal MA, Bay-Jensen AC, Mackey AL, Byrjalsen I, Bihlet AR, Boesen MP, Nielsen Bay H
Abstract Background: Asthma is a heterogeneous syndrome substantiating the urgent requirement for endotype-specific biomarkers. Dysbalance of fibrosis and fibrolysis in asthmatic lung tissue leads to reduced levels of the inflammation-protective collagen 4 (COL4A3). Objective: To delineate the degra...
July 29, 2021
Journal:
Eur Respir J
Author:
Weckmann M, Bahmer T, Rønnow S, Pech M, Vermeulen C, Faiz A, Karsdal MA, Lunding L, Oliver B, Wegmann M, Ulrich-Merzenich G, Juergens U, Duhn J, Laumonnier Y, Danov O, Sewald K, Zissler U, Jonker M, König I, Hansen G, Mutius E, Fuchs O, Dittrich AM, Schaub B, Happle C, Rabe K, de Berge M, Burgess J, Kopp M, Leeming DJ, Bülow Sand JM
The pathogenesis of psoriatic arthritis (PsA) involves inflammation and bone and soft tissue turnover. Dietary fatty acids have previously been associated with pro-inflammatory effects induced by saturated fatty acids (SFA) and anti-inflammatory effects achieved by at least some polyunsaturated fatt...
July 29, 2021
Journal:
Rheumatology International
Author:
Kristensen S, Holm Nielsen S, Schmidt Berg E, Christensen HJ, Bay-Jensen AC, Karsdal MA
To investigate the association between markers of synovial inflammation and matrix turnover (MRI-based and serum biomarkers) and knee symptoms in established knee osteoarthritis (KOA). This cross-sectional study utilised data from a randomised, multicentre placebo-controlled trial (UK-VIDEO) of vita...
July 20, 2021
Journal:
Cells
Author:
Yang X, Christian S Thudium, Bay-Jensen AC, Karsdal MA, van Santen J, Arden KN, Perry TA, Kluzek S
Abstract In inflammatory bowel disease (IBD), the chronic inflammation deeply affects the intestinal extracellular matrix. The aim of this study was to investigate if remodeling of the intestinal basement membrane type VI collagen was associated with pathophysiological changes in Crohn's disease ...
July 19, 2021
Journal:
Sci Rep
Author:
Manon-Jensen T, Mortensen JH, Lindholm M, Godskesen LE, Krag A, Karsdal MA, Kjeldsen J
Abstract Background: Idiopathic pulmonary fibrosis (IPF) is characterized by the accumulation of fibrillar collagens in the alveolar space resulting in reduced pulmonary function and a high mortality rate. Biomarkers measuring the turnover of type I and III collagen could provide valuable informa...
July 15, 2021
Journal:
Respir Res.
Author:
Leeming DJ, Jessen H, Hoyer N, Prior TS, Frederiksen P, Karsdal MA, Bendstrup E, Bülow Sand JM, Shaker SB
Background & aims: Progressive fibrosis has been identified as the major predictor of mortality in patients with non-alcoholic fatty liver disease (NAFLD). Several biomarkers are currently being evaluated for their ability to substitute the liver biopsy as the reference standard. Recent clinical...
July 10, 2021
Journal:
JHEP Rep
Author:
Erhardtsen E, Rasmussen DGK, Frederiksen P, Leeming DJ, Gluud LL, Karsdal MA, Aithal GP, Shattenberg JM, Shevell DE
Type XI collagen has been associated with tumor fibrosis and aggressiveness in patients with pancreatic ductal adenocarcinoma (PDAC). The propeptide on Type XI collagen is released into the circulation after proteolytic processing at either amino acid 253 or 511. This allows for a noninvasive biomar...
July 1, 2021
Journal:
Int J Cancer
Author:
Nissen NI, Johansen AZ, Chen IM, Karsdal MA, Diab HMH, Jørgensen LN, Sun S, Manon-Jensen T, He Y, Willumsen N, Johansen JS, Kehlet SN, Langholm LL
Abstract Objective: Dual amylin and calcitonin receptor agonists (DACRAs) are novel therapeutic agents that not only improve insulin sensitivity but also work as an adjunct to established T2DM therapies. DACRAs are currently administered once daily, though it is unknown whether DACRAs with increa...
June 29, 2021
Journal:
Molecular Metabolism
Author:
Andreassen KV, Larsen AT, Sonne N, Mohamed KE, Karsdal MA, Henriksen K
Abstract Purpose: To investigate acute changes in biochemical markers of bone and cartilage turnover in response to moderate intensity exercise with and without joint impact in healthy human subjects. Methods: A randomized, cross-over, exploratory, clinical study was conducted. Twenty healthy subjec...
June 22, 2021
Journal:
Eir K Appl Physiol
Author:
Bjerre-Bastos JJ, Nielsen Bay H, Karsdal MA, Bihlet AR, Boesen MP, Inger B, Andersen JR, Mackey AL, Thudium CS
Abstract Collagens are a primary component of the extracellular matrix and are functional ligands for the inhibitory immune receptor leukocyte-associated immunoglobulin-like receptor (LAIR)-1. LAIR-2 is a secreted protein that can act as a decoy receptor by binding collagen with higher affinity t...
June 21, 2021
Journal:
Elife
Author:
Ramos Pascoal MI, Tian L, de Ruiter EJ, Song C, Paucarmayta A, Singh A, Elshof E, Vivjer SV, Shaik J, Bosiacki J, Cusumano Z, Jensen C, Willumsen N, Karsdal MA, Liu L, Langermann S, Willems S, Flies D, Meyaard L
Abstract Abdominal aortic aneurysm (AAA) is a complex disease which is incompletely accounted for. Basement membrane (BM) Collagen IV (COL4A1/A2) is abundant in the artery wall, and several lines of evidence indicate a protective role of baseline COL4A1/A2 in AAA development. Using Col4a1/a2 hemi...
June 18, 2021
Journal:
Sci Rep
Author:
Karsdal MA, Rasmussen LM, Steffensen LB, Stubbe J, Lindholt JS, Beck HC, Overgaard M, Bloksgaard M, Genovese F, Tha MLT, Hong Lin MKT, Larsen JH, Hansen DR, Jones GT
Background The signalling peptide endotrophin is derived through proteolytic cleavage of the carboxyl-terminal during formation of type VI collagen. It is expressed by most descendants of the mesenchymal stem cells lineage, including adipocytes and fibroblasts, and have been proposed to be a centra...
May 24, 2021
Journal:
Lancet Respir Med
Author:
Staunstrup Mærsk L, Bager CL, Frederiksen P, Wulff Helge J, Brunak S, Christiansen C, Karsdal MA
Introduction: Interstitial, cartilage, and bone collagens have been proposed as biomarkers of joint deterioration in hemophilic arthropathy. The role of basement membrane (type IV and VIII) collagens as biomarkers of endothelial turnover in relation to acute joint bleeding is not understood. Method...
May 22, 2021
Journal:
J Thromb Haemost
Author:
Gopal S, Barnes RFW, Cooke EJ, Zhou JY, Levin I, Emery P, Hughes TH, Karsdal MA, Manon-Jensen T, Von Drygalski A
There is a need for antidiabetic agents successfully targeting insulin sensitivity and treating obesity control at the same time. The aim of this first-in-human study was (a) to evaluate safety and tolerability, (b) to evaluate pharmacokinetics and (c) to assess indications of receptor engagement of...
May 21, 2021
Journal:
Br J Clin Pharmacol
Author:
Henriksen K, Broekhuizen K, de Boon MIW, Karsdal MA, Christiansen C, Dillingh RM, de Kam M, Kumar R, Burggraaf J, Kamerling MCI, Bihlet AR
Background: Rupture of atherosclerotic plaques is the major cause of acute cardiovascular events. The biomarker PRO-C6 measuring Endotrophin, a matrikine of collagen type VI, may provide valuable information detecting subjects in need of intensified strategies for secondary prevention. Objective: I...
May 5, 2021
Journal:
J Intern Med
Author:
Holm Nielsen S, Edsfeldt A, Tengryd C, Gustafsson H, Shore CA, Natali A, Khan F, Bengtsson E, Karsdal MA, Leeming DJ, Nilsson J, Goncalves I, Genovese F
Background: Renal fibrosis is the hallmark of chronic kidney disease (CKD) and characterized by an imbalanced extracellular matrix remodeling. Endotrophin (ETP) is a signaling molecule released from collagen type VI (COL VI). ETP can be measured by the PRO-C6 assay, which quantifies the levels of CO...
April 29, 2021
Journal:
Nephrol Dial Transplant
Author:
Sparding N, Rasmussen DGK, Karsdal MA, Neprasova M, Maixnerova D, Satrapova V, Frausova D, Hornum M, Bartonova L, Honsova E, Kollar M, Koprivova H, Hruskova Z, Tesar V, Genovese F
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