Biomarker name
Assay description
Function
LG3
LG3 domain liberated by BMP1 from Perlecan
ECM degradation
a-Synuclein-M
A fragment of α-Synuclein released by MMP
Neurodegeneration
AGR-N
N-terminal of agrin
Basement membrane degradation
ARG
N-terminal epitope of aggrecanase mediated degradation of aggrecan
Cartilage remodeling
Arresten
Signaling fragment of type IV collagen alpha 1
Signaling peptide of the basement membrane
BGM
Neo-epitope of MMP-9,12 mediated degradation of biglycan
Pericellular matrix (proteoglycan) degradation
BREV-A
Neo-epitope of ADAMTS-4 mediated degradation of brevican
Brain tissue remodeling
C3A
Neo-epitope of ADAMTS-4,5 mediated degradation of type III collagen
Degradation of interstitial matrix and remodeling
C3C
Neo-epitope of cathepsin-B,L,S mediated degradation of type III collagen
Degradation of interstitial matrix and remodeling
C3F
A fragment of type III collagen released by FAP
ECM degradation
C4A4-HNE
A fragment of the alpha-4 chain of type IV collagen generated by human neutrophil elastase (HNE)
Mucosal inflammation
C4Ma3
Neo-epitope of MMP-2,9,12 mediated degradation of type IV collagen alpha 3 chain
Basement membrane degradation
C5CM
Neo-epitope of MMP mediated degradation of citrullinated type V collagen
N/A
C6A6
A fragment of C-terminal type VIa6 collagen
ECM turnover
C6Ma3
Neo-epitope of MMP-9 mediated degradation of type VI collagen
Interface matrix degradation
Canstatin
Canstatin, released NC1 domain of type IV collagen a2 chain
ECM signaling
CHPRO-C2
Released N-terminal pro-peptide of type II collagen for explant use
Formation of type II (cartilage collagen) in explants
COMP C3a desARG
Specific fragment of carboxypeptidase-mediated degradation of anaphylatoxin C3a
Wound healing
COMP-C5a
A fragment of N-terminal C5a anaphylatoxin
Wound healing
COMP-N
A fragment of N-terminal COMP
ECM remodeling
CRPM
Neo-epitope of MMP-mediated degradation c-reactive protein
Tissue inflammation
DCN-CS
Cathepsin S mediated decorin degradation
Pericellular matrix (proteoglycan) degradation
EL-CG
Neo-epitope of cathepsin G mediated degradation of elastin
ECM remodeling
EL-NE
Neo-epitope of neutrophil elastase mediated degradation of elastin
ECM remodeling
ELM
Neo-epitope ('441) of MMP-9,12 mediated degradation of elastin
Stromal reactivity
ELM12
Neo-epitope ('552) of MMP-9,12 mediated degradation of elastin
Stromal reactivity
ELM7
Neo-epitope of MMP-7 mediated degradation of elastin
EMC remodeling
ELP-3
Neo-epitope of proteinase-3 mediated degradation of elastin
Stromal reactivity
exAGNxI
Neo-epitope of aggrenase mediated aggrecan
N/A
exC2M
Neo-epitope of MMP mediated degradation of type II collagen for explant use
N/A
exFFGV
Neo-epitope of MMP mediated aggrecan
Cartilage remodeling
exPRO-C2
Released N-terminal pro-peptide of type II collagen
N/A
F1
Neo-epitope of thrombin mediated degradation of prothrombin
Thrombin activation
F1.2/F2
Neo-epitope of Fxa/Fva mediated degradation of prothrombin
Thrombin activation
FBN-C
C-terminal of fibronectin
ECM remodeling
FBN-EDA
Neo-epitope of MMP-8 mediated degradation of cellular fibronectin (EDA domain)
Stromal reactivity
FMODM
Neo-epitope of MMP-12 mediated degradation of fibromodulin
N/A
FXIIIAP
Neo-epitope of thrombin mediated degradation of transglutaminase FXIII
N/A
GDF-8
Myostatin (growth/differentiation factor 8)
N/A
GFAP
A fragment of Glial fibrillary acidic protein released by caspase-6
Neurodegeneration, Neuroinflammation
HSP47-C
C-terminal of heat shock protein-47
N/A
hsPRO-C6
C-terminal of released C5 domain of type VI collagen α3 chain (endotrophin)
Pro-fibrotic signaling
IL-6
Interleukin-6
N/A
iP3NP
Internal epitope in the N-terminal pro-peptide of type III collagen
N/A
LG1M
Neo-epitope of MMP-9 mediated degradation of laminin gamma 1 chain
Basement membrane degradation
MIM
Neo-epitope of MMP-9,12 mediated degradation of mimecan
ECM remodeling
n-BREV
N-terminal of brevican
Brain ECM remodeling
Neurocan-M
A fragment of Neurocan released by MMP-2
Neurogeneration, Blood-brain barrier(BBB) integrity
NFM
A fragment of neurofilament medium chain
Neurogeneration
NIC
Neo-epitope of cathepsin-S mediated degradation of nidogen
Basement membrane (proteoglycan) degradation
Osteocalcin
Osteocalcin
Bone formation
PC3X
Cross-linked N-terminal pro-peptide of type III collagen
N/A
PRO-C10
C-terminal of type X
N/A
PRO-C16
C-terminal of Type XVI collagen
Intestinal matrix turnover
PRO-C17
A fragment of C-terminal type XVII collagen
ECM formation, Epithelial damage
PRO-C18
N-terminal type XVIII collagen
Basement membrane degradation and remodeling
PRO-C18L
N-terminal of the type XVIII collagen medium and long isoforms
Basement membrane degradation and remodeling
PRO-C20
C-terminal of type XX collagen
ECM remodeling
PRO-C22
C-terminal of type XXII collagen, neoepitope specific
Connective tissue formation
PRO-C23
C-terminal of type XXIII collagen
Basement membrane remodeling
PRO-C26
C-terminal of type XXVI collagen
N/A
PRO-C28
C-terminal of type XXVIII collagen
Fibrogenesis, Fibroblast activity
PRO-C3X
Cross-linked N-terminal pro-peptide of type III collagen
ECM cross-linking
PRO-C7
A fragment of C-terminal type VII collagen
ECM formation
PRO-C9
C-terminal type IX collagen alpha chain 1 (NC-1 domain)
ECM remodeling
PRO-FIB
Neo-epitope of thrombin mediated degradation of fibrinogen
Clot formation
PROM
Neo-epitope of MMP-1 and -13 mediated degradation of prolargin
N/A
Restin-1
Neo-epitope of MMP-mediated degradation of type XV collagen
Signaling peptide of the basement membrane
Restin-2
Neo-epitope of MMP-mediated degradation of type XV collagen
Signaling peptide of the basement membrane
sauC3M
Sandwich Assay for a 30 aa fragment of collagen type III
Degradation of interstitial matrix and remodeling
SPARC-C
C-terminal of SPARC
Stromal reactivity (binding of collagens)
SPARC-M
Neo-epitope of MMP mediated degracation of SPARC
Stromal reactivity (binding of collagens)
T2CM
Neo-epitope of MMP-1 and MMP-13 mediated degradation of type II collagen
Cartilage and fibrocartilage degradation and remodeling
TAU-A
Neo-epitope of ADAM-10 mediated degradation of TAU
Cognitive loss
TAU-C
Neo-epitope of caspase-3 mediated degradation of TAU
Neuronal death
Tenascin-R
A fragment of Tenascin R
Neurodegeneration, Blood-brain barrier(BBB) integrity
TGF-beta
A fragment of LAP-TGF-b released by PLK
Active TGF-beta, ECM signaling
TIM
Neo-epitope of MMP-12 mediated degradation of titin (Cardiac isoform)
Cardiac remodeling
TIM-2
Specific fragment of MMP-12-mediated degradation of titin (Muscle isoform)
Cardiac remodeling
TSP-2
N-terminal Thrombospondin 2
N/A
uPerla
Neo-epiotpe of ADAMTS mediated degradation of perlecan
ECM remodeling
VCANM
Neo-epitope of MMP-8,12 mediated degradation of versican
ECM remodeling
VIM
Neo-epitope of MMP-2 and MMP-8 mediated degradation of Vimentin
N/A
vWF-A
Neo-epitope of ADAMTS13 mediated degradation of von willebrand factor
von Willebrand factor activation
vWF-N
Released N-terminal pro-peptide of von willebrand factor
von Willebrand factor activation
X-FIB
Neo-epitope of plasmin mediated degradation of cross-linked fibrin (sandwich assay)
Clot resolution

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