PRO-C12

C-terminal of type XII collagen. FACIT collagen measuring tissue formation, myofibroblasts and cancer-associated fibroblasts (CAFs)

Key features and values

  • Type XII collagen formation.
  • FACIT collagen.
  • Measures myofibroblasts and cancer-associated fibroblasts (CAFs).
  • Contributes to the organization and stabilization of the extracellular matrix (ECM).

Product description

The extracellular matrix (ECM) plays a crucial role in cancer progression, with increased stiffness and remodeling often driving tumor growth and metastasis. Produced by cancer-associated fibroblasts (CAFs), type XII collagen is a key regulator of ECM organization, stabilizing type I collagen fibrils, contributing to ECM stiffening, and facilitating a pro-invasive tumor microenvironment (TME). In our study, we developed the PRO-C12 ELISA, a non-invasive tool to monitor ECM stiffening and CAF activity, providing critical insights into tumor biology and metastasis risk.

Therapeutic area
Cancer

Biomarker panels

Function
FACIT collagen, Cancer-Associated Fibroblast (CAF)