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OBJECTIVES: Lysyl oxidase like 2 (LOXL2) is associated with poor prognosis in idiopathic pulmonary disease (IPF) and cancer. We developed an Enzyme-linked immunosorbent assay (ELISA) targeting the LOXL2 neo-epitope generated through the release of the signal peptide during LOXL2 maturation. DESIGN ...
November 30, 2018
Journal:
Biochem Biophys Res Commun.
Author:
Leeming DJ, Willumsen N, Holm Nielsen S, Dasgupta B, Brodmerkel C, Bager CL, Karsdal MA, Bülow Sand JM
Bone turnover is a highly regulated process, where bone resorption in the normal healthy individual always is followed by bone formation in a manner referred to as coupling. Patients with osteopetrosis caused by defective acidification of the resorption lacuna have severely decreased resorption, in ...
February 8, 2008
Journal:
Biochem Biophys Res Commun.
Author:
Neutzsky-Wulff AV, Dziegiel MH, Christiansen C, Henriksen K, Karsdal MA
Osteoclasts are the sole cells possessing the ability to resorb calcified bone matrix. This occurs via secretion of hydrochloric acid mediated by the V-ATPase and the chloride channel ClC-7. Loss of acidification leads to osteopetrosis characterized by ablation of bone resorption and increased osteo...
September 7, 2007
Journal:
Biochem Biophys Res Commun.
Author:
Nielsen RH, Karsdal MA, Sørensen MG, Dziegiel MH, Henriksen K
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