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The unique ability of the osteoclasts to resorb the calcified bone matrix is dependent on secretion of hydrochloric acid. This process is mediated by a vacuolar H+ ATPase (V-ATPase) and a chloride-proton antiporter. The structural subunit of the V-ATPase, a3, is highly specific for osteoclasts, and ...
March 13, 2012
Curr Protein Pept Sci.
Thudium CS, Jensen VK, Karsdal MA, Henriksen K
Osteoclasts are the sole cells possessing the ability to resorb calcified bone matrix. This occurs via secretion of hydrochloric acid mediated by the V-ATPase and the chloride channel ClC-7. Loss of acidification leads to osteopetrosis characterized by ablation of bone resorption and increased osteo...
September 7, 2007
Biochem Biophys Res Commun.
Nielsen RH, Karsdal MA, Sørensen MG, Dziegiel MH, Henriksen K
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