Publications
Find an abstract and a link to most of the publications produced by Nordic Bioscience
Find an abstract and a link to most of the publications produced by Nordic Bioscience
Background: Inguinal hernia disease is associated with an imbalanced collagen metabolism. Surgical stress has a negative impact on nutrients important for collagen synthesis. Objective: We hypothesized that supplementation with a combination of nutrients would enhance collagen biosynthesis in ingui...
January 3, 2020
Journal:
J Nutr
Author:
Kjaer M, Frederiksen AKS, Nissen NI, Willumsen N, Van Hall G, Jorgensen LN, Andersen JR, Årgen MS
Vastatin, a fragment derived from type VIII collagen, is one of the least studied collagen-derived matrikines. Vastatin can be detected in serum but little is known regarding the relevance of serum vastatin in colorectal cancer (CRC). In this study, serum vastatin was measured (ELISA) in 67 healthy ...
BACKGROUND AND AIMS: Hernia formation is associated with alterations of collagen metabolism. Collagen synthesis and degradation cause a systemic release of products, which are measurable in serum. Recently, we reported changes in type V and IV collagen metabolisms in patients with inguinal and incis...
April 1, 2018
Journal:
Scand J Surg
Author:
Lorentzen L, Henriksen NA, Juhl P, Mortensen JH, Ågren MS, Karsdal MA, Jorgensen LN
Matrix metalloprotease (MMP)-mediated tissue remodeling is one of the malignant changes driving colorectal cancer. Measurement of altered MMP expression/activity is not sufficient to fully understand the effect of MMP-mediated tissue remodeling. Biomarkers are required that specifically reflect the ...
May 13, 2017
Journal:
Oncol Lett
Author:
Willumsen N, Bager CL, Bay-Jensen AC, Kehlet SN, Harling H, Leeming DJ, Karsdal MA, Jorgensen LN
BACKGROUND: Throughout life, inguinal hernia develops in approximately every fourth man, some of whom develop multiple hernias. If patients at risk of developing multiple hernias could be identified by a serologic biomarker, treatment might be able to be tailored and improved. Evidence suggests that...
April 14, 2016
Journal:
Surgery
Author:
Henriksen NA, Mortensen JH, Lorentzen L, Ågren MS, Bay-Jensen AC, Jorgensen LN, Karsdal MA
Background: Disturbed metabolism in the extracellular matrix (ECM) contributes to formation of abdominal wall hernias. The aim of this study was to gain deeper insight into the ECM turnover in hernia patients by analyzing serum biomarkers specifically reflecting collagen synthesis and breakdown in t...
February 1, 2015
Journal:
Surgery
Author:
Henriksen NA, Mortensen JH, Sorensen LT, Bay-Jensen AC, Agren MS, Jorgensen LN, Karsdal MA
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