That's where endotrophin, a product of collagen formation, comes into the picture. Endotrophin reflects the activity of key collagen-producing cells: fibroblasts. Endotrophin measured by the PRO-C6 assay, can identify HFpEF patients with a very aggressive endotype, highly affected by fibrosis.
Among all HFpEF endotypes, there is another, unique, patient group – the ones with high fibroblast activity, which can be quantified by PRO-C6. It doesn’t matter if you’re old, obese, or frail, your PRO-C6 can still be high.