Serum Quantification of Aggrecanase-Generated ARGS Fragments
Osteoarthritis is a serious disease. It affects more than 300 million people across the world. It’s a leading cause of disability among older adults. Therefore, it has a considerable impact on an individual’s quality of life and a huge economic burden on society.
We redeveloped a highly sensitive and robust sandwich immunoassay, huARGS, for detecting ARGS fragments generated by up-regulated proteases, ADAMTS-4/-5, during osteoarthritis.
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