Our Renal and Cardiovascular Research team showed that biomarkers of collagen remodeling measured in urine and circulation at baseline are associated with the rate of decline in kidney function in patients with autosomal dominant polycystic kidney disease (ADPKD). This disease is hereditary, wherein cysts - small fluid sacs - develop in the kidneys.

In the study (DIPAK-1), we measured the effect of lanreotide on patients with stage 3 chronic kidney disease. The following demographics were involved:

 

DIPAK-1 demographics

We have selected a number of biomarkers best suited to assess the effect of lanreotide:

  • PRO-C3, measuring collagen type III formation in serum and urine (interstitial matrix turnover)
  • C3M, measuring collagen type III degradation in serum and urine (interstitial matrix turnover)
  • PRO-C6, measuring collagen type VI formation in serum and urine. Also measures the release of the bioactive fragment endotrophin, associated with pro-fibrotic and pro-inflammatory processes (interstitial matrix turnover)
  • LG1M, measuring Laminin gamma 1 degradation in serum and urine (basement membrane turnover)

Kidney biomarker data compared to baseline values

Predicting decline in kidney function with prognostic biomarkers

The data we found implies that fibrogenesis may be an important pathophysiological process driving ADPKD disease progression. In addition, the use and development of drugs that interfere with fibrogenesis may be promising to halt disease progression in ADPKD. However, we still need to validate in an independent cohort, preferably in early-stage disease.

We believe it is time to put kidney fibrosis more in the center - even in diseases where other aspects (such as kidney volume) are the focus of attention. At Nordic Bioscience, we have the tools to do so. 

 

Read more about our biomarkers in chronic kidney diseases.

Please don't hesitate to contact us if you have any questions or other inquiries.

Please don't hesitate to contact us if you have any questions or other inquiries.

Are you interested in learning more about Nordic Bioscience?
Enter your information in the form and a representative will contact you shortly.

By submitting this form you agree to our terms and conditions.