Category: Videos

Why measure the right epitope of the right protein

Posted on by Claire Hornung

A targeted approach in contrast to broad total protein arrays

When we talk about protein quantification, it’s important to talk about the role collagens play in major chronic diseases. As extracellular matrix research is gaining more and more traction, it’s prime time to highlight how they can guide precision medicine development.

Dr. Morten Karsdal, CEO of Nordic Bioscience, discusses the importance of finding the right epitope of the right protein in clinical trials.

If you wish to find out more about the extracellular matrix or our technology, visit our YouTube channel!

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    Osteoarthritis Biomarkers – Serum Quantification of Aggrecanase-Generated ARGS Fragments

    Posted on by Claire Hornung

    Serum Quantification of Aggrecanase-Generated ARGS Fragments

    Osteoarthritis is a serious disease. It affects more than 300 million people across the world. It’s a leading cause of disability among older adults. Therefore, it has a considerable impact on an individual’s quality of life and a huge economic burden on society.

    We redeveloped a highly sensitive and robust sandwich immunoassay, huARGS, for detecting ARGS fragments generated by up-regulated proteases, ADAMTS-4/-5, during osteoarthritis.

    Watch more videos about how our biomarker can increase clinical trial success rates on our YouTube channel!

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      Joint Tissue Remodeling: Joint and Connective Tissue Disorder Profiling

      Posted on by Claire Hornung

      Joint and Connective Tissue Disorder Profiling

      According to conservative estimates, nearly 26% of all adults in the United States are expected to have at least one form of arthritis by 2040. The tissues of the joints are composed primarily of collagens.

      Collagens are remodeled as part of the normal homeostasis of the joint – that is, collagens are broken down and rebuilt as part of the repair and maintenance mechanisms of the tissue.

      When this balance is disrupted, there is a net breakdown of joint tissue. Learn more how Protein Fingerprint biomarkers can quantify this tissue turnover directly in a serum sample.

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        Biomarkers in Drug Development

        Posted on by Claire Hornung

        The Protein Fingerprint Technology

        Through our Protein Fingerprint technology, we identify fragments of the Extracellular Matrix (ECM) that are released from affected tissues and develop blood-based biomarker assays to quantify disease activity with the aim of precision medicine.

        By quantifying tissue remodeling, our biomarkers provide true prognostic and predictive value, as we can select the patients who are most likely to respond to a given treatment and thereby function as surrogate biomarkers for clinical trials. Our biomarker assays not only enable faster drug development but also improve disease outcomes for chronically ill patients by predicting treatment response.

        Watch more videos about Nordic Bioscience’s biomarkers and the ECM on our YouTube channel!

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          Use of Translational Biomarkers in Pulmonary Fibrosis

          Posted on by Claire Hornung

          PRO-C6 as a pharmacodynamic biomarker

          During the development of pulmonary fibrosis, there are changes in the extracellular matrix. We see the destruction of the basement membrane and the formation of various collagens in the interstitial matrix.

          We can monitor these changes in the ECM in a blood sample using Protein Fingerprint biomarker technology.

          Watch more videos about the extracellular matrix and the Protein Fingerprint on our YouTube channel!

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            Endotrophin as a Novel Biomarker in HFpEF – Identification of a High-risk Endotype

            Posted on by Claire Hornung

            Identification of a High-risk Endotype

            Heart failure with preserved ejection fraction (HFpEF) is a highly complex and heterogeneous syndrome that causes substantial morbidity and mortality, positioning this disease as one of the biggest unmet medical needs today.

            The past years have seen great scientific and clinical efforts on elucidating the driving mechanisms, but much remains unknown and successful therapies at still largely absent.

            One of the biggest challenges to treating HFpEF is the heterogeneous nature of the syndrome. Risk assessment by conventional biomarkers has not led to any significant therapies, but selection of a more homogenous patient population might be the way forward.

            Fibrosis is a hallmark feature of HFpEF pathology, acting as a driver of outcome. Understanding the intricate pathways that lead to fibrogenesis, and how they ultimately impact pathogenesis, is important for understanding how to treat HFpEF. We have developed a biomarker of fibroblast activity, PRO-C6, which independently and with high precision can identify a subset of HFpEF patients with a very elevated risk of adverse outcome.

            Watch more videos about Nordic Bioscience’s biomarkers and technology on our YouTube channel!

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              Tumor Fibrosis Biomarkers

              Posted on by Claire Hornung

              Guiding Immune Checkpoint Inhibitor Therapy

              Emerging evidence indicates that one central common denominator of resistance to immune checkpoint inhibitors may be fibrotic activity characterized by collagen production by cancer-associated fibroblasts (CAFs).

              Consequent to increased fibroblast activity, specific collagen fragments are released into the circulation and can be used as non-invasive biomarkers assessed in a liquid biopsy such as serum or plasma. PRO-C3 quantifies the formation of type III collagen and can therefore be used as a non-invasive biomarker of tumor fibrosis.

              Watch more videos about Nordic Bioscience’s biomarkers and technology on our YouTube channel!

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                Early Detection of Neuron Loss in Alzheimer’s

                Posted on by Claire Hornung

                Tau-C Biomarker

                The Tau-C biomarker assay uses an antibody that specifically detects a fragment of tau produced by caspase-3. This assay is capable of detecting neuron loss already in the early stages of Alzheimer’s disease before the onset of symptoms.

                After establishing the assay, we performed measurements in blood samples from individuals with brain injury, as brain injury is known to result in loss of neurons and release of fragments into the bloodstream.

                Watch more videos about our biomarkers and the Protein Fingerprint on our YouTube channel!

                Watch more videos about our biomarkers and the Protein Fingerprint on our YouTube channel!

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                  Extracellular Matrix Animation

                  Posted on by Claire Hornung

                  Quantifying Tissue Remodeling Through the Protein Fingerprint

                  The human body is formed from a single cell that divides into trillions of cells that make up the unique organs of our bodies. All cells in the human body carry the same genetic material.

                  The only way they know how to interact, behave, and form the organs is because of the context that surrounds them. This context is called the extracellular matrix.

                  Watch more videos about the extracellular matrix and the Protein Fingerprint on our YouTube channel!

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                    Why Collagens Matter – The Importance of the Extracellular Matrix (ECM)

                    Posted on by Claire Hornung

                    The Importance of the Extracellular Matrix (ECM)

                    Collagens are the most important structural component of all tissues, just like the beams of the Eiffel Tower. We need these collagens and beams in optimal quality and strength, otherwise disasters will occur.

                    Every organ in the body needs constant repair to stay healthy. As a result, collagens are remodeled, which supports these tissues. If we could understand these signals of regeneration, how tissues are remodeled, we could cure most diseases, renew the organs of the body, and reverse chronic diseases. 

                    Watch more videos about collagens and the ECM on our YouTube channel!

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