Dermatology

Biomarkers for Dermatology

In dermatology, diseases like systemic sclerosis and psoriasis are characterized by high tissue turnover. Several biomarkers have shown potential as valuable tools in developing diagnostic and therapeutic strategies for these conditions. Our biomarkers are versatile and can be applied across a broad range of dermatological diseases, including atopic dermatitis, hidradenitis suppurativa, psoriasis, scleroderma, and more.

 

The different skin layers

Nordic Bioscience can quantify proteins located in different layers of the skin

The skin is the largest organ of the human body and consists of three different layers; epidermis, dermis and subcutis. These three layers have distinct tissue architectures and functions.

Skin functions are dependent on the complex composition of extracellular matrix (ECM) proteins. The ECM of the skin can be divided into the epidermal ECM, epidermal basement membrane and the papillary/reticular ECM. The major ECM components of the skin are collagens, which are located in the different tissue compartments to maintain tissue architecture.

The Nordic ProteinFingerPrint Technology™ allows for the quantification of proteins located in the different layers of the skin, and also the quantification of immune cell activity involved in different pathologies (mast cells, neutrophils, fibroblasts, and macrophages).

Biomarkers for atopic dermatitis

Atopic dermatitis (AD) is a chronic, inflammatory skin condition with significant patient heterogeneity and links to broader type II inflammatory diseases such as asthma and allergic rhinitis. Understanding disease mechanisms requires precise tools—tissue-specific biomarkers provide quantifiable insights into epidermal and dermal damage, as well as immune cell activity.

Nordic Bioscience’s ProteinFingerPrint Technology™ offers a clinically validated, ECM-focused biomarker platform that enables precise disease characterization, supports targeted therapy development, and facilitates scalable diagnostic solutions. This approach enhances precision medicine by identifying distinct pathological processes and guiding effective, individualized treatment strategies.

Biomarkers for hidradenitis suppurutiva

Hidradenitis suppurativa (HS) is a chronic, systemic skin disease marked by intense tissue remodeling and immune activation, leading to painful, recurrent lesions. Nordic Bioscience’s ProteinFingerPrint Technology™ enables quantification of epidermal and dermal damage, as well as immune cell activity, providing critical insights into HS pathogenesis.

These ECM-based biomarkers support improved diagnosis, stratification, and treatment monitoring—addressing key unmet clinical needs. Their validated specificity allows for precision medicine approaches, more reliable therapy selection, and accelerated drug development by targeting distinct biological mechanisms driving HS.

Biomarkers for psoriasis

Psoriasis is a chronic inflammatory skin disorder marked by excessive extracellular matrix remodeling and heightened immune cell activity, resulting in painful, scaly plaques. Nordic Bioscience’s ProteinFingerPrint Technology™ delivers tissue-specific biomarkers that quantify epidermal and dermal damage, enabling precise assessment of disease activity and progression.

These ECM-based markers support a targeted understanding of psoriasis pathogenesis, improve therapy selection, and provide critical data for clinical trials. Their specificity surpasses broad-spectrum omics approaches, making them integral to advancing precision medicine and individualized treatment strategies in dermatology.

Biomarkers for scleroderma (systemic sclerosis)

Systemic skin diseases with local manifestations are characterized by excessive tissue remodeling and immune cell activity. Tissue-specific biomarkers, quantifying and monitoring immune cell activity, are key advantages when we want to understand the disease mechanisms and complexity in systemic sclerosis and lead to targeted successful treatments. On this page, we explain how our biomarkers for systemic sclerosis can provide such crucial value.

Translational models in dermatology

Nordic Bioscience effectively integrates innovative translational models with ProteinFingerPrint Technology™ to translate findings efficiently. By using the same biomarkers throughout various clinical development stages, they create a seamless link between preclinical models and clinical applications. This strategically chosen development pathway significantly boosts the efficiency of drug development pipelines.

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    Nordic Bioscience’s assays, products, and services are for research use only and are not intended for medical or diagnostic purposes.