Month: January 2022

Guiding Immune Checkpoint Inhibitor Therapy

Emerging evidence indicates that one central common denominator of resistance to immune checkpoint inhibitors may be fibrotic activity characterized by collagen production by cancer-associated fibroblasts (CAFs).

Consequent to increased fibroblast activity, specific collagen fragments are released into the circulation and can be used as non-invasive biomarkers assessed in a liquid biopsy such as serum or plasma. PRO-C3 quantifies the formation of type III collagen and can therefore be used as a non-invasive biomarker of tumor fibrosis.

Watch more videos about Nordic Bioscience’s biomarkers and technology on our YouTube channel!

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Tau-C Biomarker

The Tau-C biomarker assay uses an antibody that specifically detects a fragment of tau produced by caspase-3. This assay is capable of detecting neuron loss already in the early stages of Alzheimer’s disease before the onset of symptoms.

After establishing the assay, we performed measurements in blood samples from individuals with brain injury, as brain injury is known to result in loss of neurons and release of fragments into the bloodstream.

Watch more videos about our biomarkers and the Protein Fingerprint on our YouTube channel!

Watch more videos about our biomarkers and the Protein Fingerprint on our YouTube channel!

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Quantifying Tissue Remodeling Through the Protein Fingerprint

The human body is formed from a single cell that divides into trillions of cells that make up the unique organs of our bodies. All cells in the human body carry the same genetic material.

The only way they know how to interact, behave, and form the organs is because of the context that surrounds them. This context is called the extracellular matrix.

Watch more videos about the extracellular matrix and the Protein Fingerprint on our YouTube channel!

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The Importance of the Extracellular Matrix (ECM)

Collagens are the most important structural component of all tissues, just like the beams of the Eiffel Tower. We need these collagens and beams in optimal quality and strength, otherwise disasters will occur.

Every organ in the body needs constant repair to stay healthy. As a result, collagens are remodeled, which supports these tissues. If we could understand these signals of regeneration, how tissues are remodeled, we could cure most diseases, renew the organs of the body, and reverse chronic diseases. 

Watch more videos about collagens and the ECM on our YouTube channel!

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