Serum markers of liver fibrosis: combining the BIPED classification and the neo-epitope approach in the development of new biomarkers.

January 1, 2010

Dis Markers

Abstract BACKGROUND Fibrosis is a central histological feature of chronic liver diseases and is characterized by the accumulation and reorganization of the extracellular matrix. The gold standard for assessment of fibrosis is histological evaluation of a percutaneous liver biopsy. Albeit a considerable effort have been invested in finding alternative non-invasive approaches, these have not been […]

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Investigations of inter- and intraindividual relationships between exposure to oral salmon calcitonin and a surrogate marker of pharmacodynamic efficacy.

January 1, 2010

Eur J Clin Pharmacol

Abstract AIMS The aims of the study were to investigate interindividual variations in the bioavailability of salmon calcitonin (sCT) following single oral 0.8 mg doses at three different times of the day, and intraindividual variation in sCT bioavailability at each end of a 14-day treatment period. We also investigated correlations between exposure to sCT and […]

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Anisotropic diffusion tensor applied to temporal mammograms: an application to breast cancer risk assessment.

January 1, 2010

Annu Int Conf IEEE Eng Med Biol Soc

Abstract Breast density is considered a structural property of a mammogram that can change in various ways explaining different effects of medicinal treatments. The aim of the present work is to provide a framework for obtaining more accurate and sensitive measurements of breast density changes related to specific effects like Hormonal Replacement Therapy (HRT) and […]

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Classification of protein profiles using fuzzy clustering techniques: an application in early diagnosis of oral, cervical and ovarian cancer.

January 1, 2010

Annu Int Conf IEEE Eng Med Biol Soc

Abstract Present study has brought out a comparison of PCA and fuzzy clustering techniques in classifying protein profiles (chromatogram) of homogenates of different tissue origins: Ovarian, Cervix, Oral cancers, which were acquired using HPLC-LIF (High Performance Liquid Chromatography-Laser Induced Fluorescence) method developed in our laboratory. Study includes 11 chromatogram spectra each from oral, cervical, ovarian […]

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