Category: Webinars

Tumor Fibrosis in Cancer: Fibroblast Activities and New Biomarkers

Posted on by Claire Hornung

Watch this insightful webinar on tumor fibrosis, where we will explore the latest advancements in cancer research with leading experts in the field.

This webinar will provide a unique opportunity to hear from experts in the field and gain valuable insights into the latest advancements in tumor fibrosis research. Join us to learn about cutting-edge approaches to developing new therapeutic targets, and the use of biomarkers for patient stratification and evaluating treatment efficacy.

Watch the replay here

Agenda

Opening of the session – Dr. Morten A. Karsdal

Tumor Fibrosis and Clinical Outcomes: Underlying Mechanisms – Dr. Saurabh Gupta

The Collagen Landscape in Cancer: Fibroblast Activities and New Biomarkers – Dr. Nicholas Willumsen 

Unique and unexpected role of collagens in cancer – Dr. Raghu Kalluri 

Question from the chat

Expert line-up

Dr. Raghu Kalluri (Professor and Chairman, Department of Cancer Biology, University of Texas MD Anderson Cancer Center), is an expert in the cellular microenvironment and will discuss, among others, the unique and unexpected role of collagens in cancer.

Dr. Saurabh Gupta (Senior Director, Clinical Biomarkers Oncology, Precision Medicine), Bristol-Myers Squibb, is a clinical drug development and biomarker research expert and will provide valuable insights into the underlying mechanisms of tumor fibrosis and the association with clinical outcomes.

Dr. Nicholas Willumsen (Director, Oncology, Nordic Bioscience), will focus on the development and validation of blood-based biomarkers to quantify tumor fibrosis in serum from cancer patients and discuss how this may inform on cancer-associated fibroblast (CAF) activity and subtyping.

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    HFpEF and Extracellular Matrix Dysregulation: Novel Treatment Strategies

    Posted on by Claire Hornung

    The session will include a stimulating talk by Dr. Morten Karsdal on understanding the mysteries of the different types of collagens. Dr. Alexander Lynge Reese-Petersen will then spotlight collagen type VI and its relationship to various pathologies, as well as the pharmacological and biological properties of the dangerous hormone Endotrophin.

    Scientific topics

    Extracellular matrix (ECM) dysregulation is the founding cause of tissue fibrosis, a process driving more than 50 pathologies and most chronic diseases. Fibrosis may develop both consequent to either an increase in tissue formation or a decrease in tissue degradation.

    ​​​​​​​Understanding the ECM and the central components of the basement membrane and interstitial ECM will lead to a better understanding of disease mechanisms and to novel treatment strategies. This may be a central part in precision medicine strategies to target the right patients.

    Watch replay here

    Dr. Morten Karsdal will talk about:

    • ECM remodeling is the common denominator of all fibro-inflammatory disorders
    • Collagens have signaling molecules that we need to understand to understand how the ECM affects cells in fibrosis and tissue turnover
    • Endotrophin and other collagen fragments (Vastatin, Tumstatin and Endostatin) are potential signaling molecules derived from the processing of the collagens in the ECM
    • Understanding ECM turnover may lead to better insight into disease mechanisms and better biological understanding of individual patients

    Dr. Alexander Reese’s presentation will cover:

    • ECM biomarkers are elevated in chronic pathologies and have prognostic significance for outcome. How can we best use this to guide drug development?
    • Endotrophin, a collagen hormone in multi-organ diseases
    • Endotrophin in HFpEF, a potentially treatable high-risk endotype
    • Use of the tissue turnover profile for patient selection

    Get in touch

    Are you interested in exploring collaboration possibilities?
Enter your information in the form and a representative will contact you shortly.
    +45 4452 5252 Contact us via email!