Biomarkers

A fragment of the C-terminal propeptide of type V fibrillar collagen, enabling non-invasive monitoring of extracellular matrix, myfibroblast and cancer-associated fibroblast (CAFs) formation, indicating fibrotic activity in hepatic and oncological conditions.

A citrullinated and matrix metalloproteinase-degraded fragment of vimentin, enabling non-invasive monitoring of macrophage-driven inflammation and tissue remodeling across autoimmune and fibrotic diseases.

A fragment of aggrecan from IGD1-2 released by ADAMTS-4/5, enabling non-invasive assessment of cartilage degradation and turnover in joint diseases.

A neo-epitope fragment of type I collagen generated by MMP activity, quantifying pathological soft tissue destruction and extracellular matrix turnover.

A neo-epitope fragment of the α3 chain of type IV collagen generated by matrix metalloproteinase activity, enabling non-invasive assessment of basement membrane degradation and extracellular matrix remodeling in chronic inflammatory and fibrotic diseases.

A neo-epitope fragment of the α6 chain of type VI collagen, enabling non-invasive monitoring of dermal extracellular matrix remodeling and fibroblast activation in inflammatory skin disorders.

A fragment of type VIa1 collagen released by MMP-2. Special beaded filament collagen measuring interstitial ECM destruction. A neo-epitope fragment of type VI collagen generated by matrix metalloproteinase activity, enabling non-invasive assessment of interstitial extracellular matrix remodeling in fibrotic and oncological conditions.

A neo-epitope fragment of type VII collagen generated by matrix metalloproteinase activity, enabling non-invasive monitoring of dermal-epidermal junction integrity and tissue remodeling in fibrotic and inflammatory skin disorders.

A neo-epitope fragment of cartilage intermediate layer protein 1 generated by matrix metalloproteinase activity, enabling non-invasive monitoring of cartilage degradation and disease activity in rheumatic conditions.

A cross-linked C-terminal telopeptide of type I collagen released during bone resorption, reflecting osteoclastic bone degradation.