Biomarkers

A neo-epitope fragment of elastin generated by neutrophil elastase activity, enabling non-invasive monitoring of extracellular matrix degradation and inflammation in chronic respiratory and gastrointestinal diseases.

A neo-epitope fragment of type III collagen released during extracellular matrix remodeling, enabling non-invasive quantification of active fibrogenesis and dynamic assessment of fibrosis progression and treatment response. Elecsys automated version: An in vitro diagnostic (IVD)-labelled assay developed in collaboration with Roche Diagnostics. It is intended for clinical use under regulated conditions.

A fragment of elastin cleaved by proteinase 3, enabling non-invasive monitoring of neutrophil-driven extracellular matrix degradation and inflammation in chronic diseases.

A neo-epitope fragment of the laminin γ1 chain generated by matrix metalloproteinase activity, enabling non-invasive monitoring of basement membrane remodeling and fibrotic activity in chronic diseases.

A fragment of the N-terminal midregion of osteocalcin, reflecting bone formation activity.

A fragment of the NC1 domain of type X collagen, enabling non-invasive monitoring of chondrocyte hypertrophy and cartilage matrix remodeling in osteoarthritis and inflammatory joint diseases.

A fragment of the C-terminal domain of type XVI FACIT collagen, enabling non-invasive monitoring of extracellular matrix remodeling and fibrostenotic activity in gastrointestinal disorders such as colorectal cancer and Crohn's disease.

A fragment of the N-terminal propeptide of type IIB fibrillar collagen, enabling non-invasive monitoring of cartilage formation and chondrocyte anabolic activity in joint diseases such as osteoarthritis.

A fragment of the 7S domain of type IV collagen, enabling non-invasive monitoring of basement membrane formation and epithelial extracellular matrix remodeling in fibrotic and inflammatory diseases.

A fragment of the C-terminal domain of type VII collagen, the only anchoring fibril, enabling non-invasive monitoring of dermal-epidermal junction integrity and extracellular matrix formation in skin and intestinal tissue remodeling.