Biomarkers

A fragment of type VIa1 collagen released by MMP-2. Special beaded filament collagen measuring interstitial ECM destruction. A neo-epitope fragment of type VI collagen generated by matrix metalloproteinase activity, enabling non-invasive assessment of interstitial extracellular matrix remodeling in fibrotic and oncological conditions.

A neo-epitope fragment of type VII collagen generated by matrix metalloproteinase activity, enabling non-invasive monitoring of dermal-epidermal junction integrity and tissue remodeling in fibrotic and inflammatory skin disorders.

A neo-epitope fragment of elastin generated by cathepsin G activity, enabling non-invasive monitoring of elastin degradation and extracellular matrix remodeling in dermatology and chronic respiratory diseases.

A neo-epitope fragment of elastin generated by neutrophil elastase activity, enabling non-invasive monitoring of extracellular matrix degradation and inflammation in chronic respiratory and gastrointestinal diseases.

A neo-epitope fragment of type III collagen released during extracellular matrix remodeling, enabling non-invasive quantification of active fibrogenesis and dynamic assessment of fibrosis progression and treatment response. Elecsys automated version: An in vitro diagnostic (IVD)-labelled assay developed in collaboration with Roche Diagnostics. It is intended for clinical use under regulated conditions.

A fragment of elastin cleaved by proteinase 3, enabling non-invasive monitoring of neutrophil-driven extracellular matrix degradation and inflammation in chronic diseases.

A fragment of fibronectin generated by matrix metalloproteinase activity, enabling non-invasive monitoring of extracellular matrix remodeling and fibrotic activity in chronic tissue disorders.

A fragment of nidogen-1 cleaved by cathepsin S, enabling non-invasive monitoring of basement membrane degradation and tumor microenvironment remodeling in cancer.

A fragment of the ectodomain of type XVII collagen, enabling non-invasive monitoring of epithelial damage and basement membrane remodeling in skin and gastrointestinal disorders.

C-terminal of type XXII collagen. FACIT collagen measuring tissue formation, molecular bridging and tissue organization. A fragment of the C-terminal domain of type XXII FACIT collagen, enabling non-invasive monitoring of extracellular matrix organization, molecular bridging and tumor-associated fibrosis across multiple solid tumor types.