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Increased basement membrane turnover and strongly attenuated interstitial matrix turnover is a key pathological feature of haemophilia.
November 1, 2017
Haemophilia
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Modifiable risk factors promoting neurodegeneration is associated with two novel brain degradation markers measured in serum.
September 1, 2017
Neurochem Int
Abstract There has been limited success with blood-based biomarkers of neurodegeneration. One perceived reason is that blood has no direct contact to the brain. Recently developed blood-based biomarkers of tau-degradation have shown promise as potential tools for peripheral assessment of neurodegeneration; however, factors contributing to the levels of these in blood are poorly understood. Using […]
Low vs. high haemoglobin trigger for transfusion in vascular surgery: protocol for a randomised trial.
September 1, 2017
Acta Anaesthesiol Scand
Abstract BACKGROUND In patients with cardiovascular disease, guidelines for administration of red blood cells (RBC) are mainly based on studies outside the vascular surgical setting with the recommendation to use a haemoglobin (hb) trigger-level lower than by guidelines from The European Society for Vascular Surgery. Restricting RBC transfusion may affect blood O transport with a […]
Cathepsin-S degraded decorin are elevated in fibrotic lung disorders – development and biological validation of a new serum biomarker.
August 9, 2017
BMC Pulm Med
Abstract BACKGROUND Decorin is one of the most abundant proteoglycans of the extracellular matrix and is mainly secreted and deposited in the interstitial matrix by fibroblasts where it plays an important role in collagen turnover and tissue homeostasis. Degradation of decorin might disturb normal tissue homeostasis contributing to extracellular matrix remodeling diseases. Here, we present […]
Type I and III collagen turnover is increased in axial spondyloarthritis and psoriatic arthritis. Associations with disease activity and diagnostic capacity.
August 1, 2017
Clin Exp Rheumatol
Abstract OBJECTIVES To investigate the turnover of type I and III collagen by neo-epitope markers in patients with axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA). METHODS Patients with PsA (n=101) or axSpA (n=110) and healthy subjects (n=120) were included. Demographic and clinical data were recorded. Markers of type I and III collagen were quantified by […]
Cohort Profile: The Prospective Epidemiological Risk Factor (PERF) study.
August 1, 2017
Int J Epidemiol
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Misbalance in type III collagen formation/degradation as a novel serological biomarker for penetrating (Montreal B3) Crohn’s disease.
July 1, 2017
Aliment Pharmacol Ther
Abstract BACKGROUND Misbalances in extracellular matrix turnover are key factors in the development of stricturing (Montreal B2) and penetrating (Montreal B3) Crohn’s disease. AIM To determine whether serological markers for collagen formation and degradation could serve as biomarkers for complications of Crohn’s disease. METHODS Serum biomarkers for type I, III, V and VI collagen formation […]
Serological biomarkers detect active joint destruction and inflammation in patients with haemophilic arthropathy.
July 1, 2017
Haemophilia
Abstract INTRODUCTION Progressive arthropathy caused by recurrent joint bleeds is a severe complication in haemophilia. AIM We investigated whether biomarkers of cartilage and bone degradation, and inflammation were altered in haemophilia patients and whether these biomarkers could identify haemophilia patients with arthropathy. METHODS Serum from 35 haemophilia patients with varying degrees of arthropathy and 43 […]
Metabolic Syndrome, Insulin Resistance, and Cognitive Dysfunction: Does Your Metabolic Profile Affect Your Brain?
July 1, 2017
Diabetes
Abstract Dementia and type 2 diabetes are both characterized by long prodromal phases, challenging the study of potential risk factors and their temporal relation. The progressive relation among metabolic syndrome, insulin resistance (IR), and dementia has recently been questioned, wherefore the aim of this study was to assess the potential association among these precursors of […]
Biomarker of extracellular matrix remodelling C1M and proinflammatory cytokine interleukin 6 are related to synovitis and pain in end-stage knee osteoarthritis patients.
July 1, 2017
Pain
Abstract Little is known about local and systemic biomarkers in relation to synovitis and pain in end-stage osteoarthritis (OA) patients. We investigated the associations between the novel extracellular matrix biomarker, C1M, and local and systemic interleukin 6 (IL-6) with synovitis and pain. Serum C1M, plasma, and synovial fluid IL-6 (p-IL-6, sf-IL-6) were measured in 104 […]
