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ECM remodeling markers are altered by anti-fibrotic compounds in human skin ex vivo model
August 28, 2026
Clinically validated markers of extracellular matrix remodeling are altered by anti-fibrotic compounds in a human skin ex vivo model
Introduction
Skin pathologies, such as hidradenitis suppurativa and scleroderma, are characterized by excessive extracellular matrix (ECM) remodeling. Clinically validated ECM neo-epitope biomarkers, related to progression, treatment response, and outcomes, may be useful for the evaluation of potential anti-inflammatory and anti-fibrotic effects.
Poster
Conclusion
This study found that an MMP-inhibitor and anti-fibrotic decreased biomarkers of ECM remodeling in a human skin ex vivo model and may potentially be used as a tool for evaluating anti-inflammatory and anti-fibrotic compounds in a 3D skin structure.
