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Correction: Predictive value of BMD for hip and other fractures: a meta-analysis to update FRAX.
April 1, 2026
Osteoporos Int
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Correction: A meta-analysis of previous falls and subsequent fracture risk in cohort studies.
March 24, 2026
Osteoporos Int
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Predictive value of BMD for hip and other fractures: a meta-analysis to update FRAX.
March 12, 2026
Osteoporos Int
Abstract UNLABELLED The relationship between bone mineral density (BMD) at the femoral neck and fracture risk was determined in a meta-analysis of primary data of 307205 men and women from 53 cohort studies. Low BMD was an important predictor of fracture risk, particularly for hip fracture. INTRODUCTION This study aimed to quantify the relationship between […]
A meta-analysis of smoking and fracture risk to update the FRAX® tool.
March 4, 2026
Osteoporos Int
Abstract UNLABELLED In this meta-analysis of international cohorts, current smoking is confirmed as a significant BMD-independent predictor of future fracture with a stronger relationship in men than in women. A causative and reversible effect of smoking on fracture risk is suggested by past smoking having a significantly lower risk than current smoking. PURPOSE In this […]
Family history of fracture and fracture risk: a meta-analysis to update the FRAX® risk assessment tool.
September 1, 2025
Osteoporos Int
Abstract UNLABELLED In the largest meta-analysis of international cohorts to date, a family history of fracture is confirmed as a significant BMD-independent predictor of future fracture risk. Parental and sibling histories of fracture carry the same significance for future fracture, including the impact of family hip fracture on future hip fracture risk. PURPOSE We have […]
Rheumatoid arthritis and subsequent fracture risk: an individual person meta-analysis to update FRAX.
April 1, 2025
Osteoporos Int
Abstract UNLABELLED The relationship between rheumatoid arthritis (RA) and fracture risk was estimated in an international meta-analysis of individual-level data from 29 prospective cohorts. RA was associated with an increased fracture risk in men and women, and these data will be used to update FRAX®. INTRODUCTION RA is a well-documented risk factor for subsequent fracture […]
A meta-analysis of previous falls and subsequent fracture risk in cohort studies.
March 1, 2024
Osteoporos Int
Abstract UNLABELLED The relationship between self-reported falls and fracture risk was estimated in an international meta-analysis of individual-level data from 46 prospective cohorts. Previous falls were associated with an increased fracture risk in women and men and should be considered as an additional risk factor in the FRAX® algorithm. INTRODUCTION Previous falls are a well-documented […]
Previous fracture and subsequent fracture risk: a meta-analysis to update FRAX.
December 1, 2023
Osteoporos Int
Abstract UNLABELLED A large international meta-analysis using primary data from 64 cohorts has quantified the increased risk of fracture associated with a previous history of fracture for future use in FRAX. INTRODUCTION The aim of this study was to quantify the fracture risk associated with a prior fracture on an international basis and to explore […]
Update of the fracture risk prediction tool FRAX: a systematic review of potential cohorts and analysis plan.
October 1, 2022
Osteoporos Int
Abstract UNLABELLED We describe the collection of cohorts together with the analysis plan for an update of the fracture risk prediction tool FRAX with respect to current and novel risk factors. The resource comprises 2,138,428 participants with a follow-up of approximately 20 million person-years and 116,117 documented incident major osteoporotic fractures. INTRODUCTION The availability of […]
Is bone quality associated with collagen age?
September 1, 2009
Osteoporos Int
Abstract The World Health Organization defines osteoporosis as a systemic disease characterized by decreased bone tissue mass and microarchitectural deterioration, resulting in increased fracture risk. Since this statement, a significant amount of data has been generated showing that these two factors do not cover all risks for fracture. Other independent clinical factors, such as age, […]
