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Biochemical markers for monitoring response to therapy: evidence for higher bone specificity by a novel marker compared with routine markers.

May 1, 2008

Cancer Epidemiol Biomarkers Prev

Abstract The aim of the present study was to compare a novel marker for high bone turnover with two routine markers for screening in prostate cancer patients. The markers were evaluated in two studies: (a) a cross-sectional study of 170 prostate cancer patients with local disease stratified by +/-lymph node metastases (N 0, N1) compared […]

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Oestrogen exhibits type II collagen protective effects and attenuates collagen-induced arthritis in rats.

April 1, 2008

Clin Exp Immunol

Abstract As anti-inflammatory treatments used in rheumatoid arthritis, such as glucocorticoids, often result in secondary detrimental effects on bone health, the objective of this study was to investigate the effects of oestrogen therapy (ET) on the development and activity of collagen-induced arthritis (CIA) in rats, with a focus on assessment of chondroprotective effects using biomarkers […]

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Automatic shape model building based on principal geodesic analysis bootstrapping.

April 1, 2008

Med Image Anal

Abstract We present a novel method for automatic shape model building from a collection of training shapes. The result is a shape model consisting of the mean model and the major modes of variation with a dense correspondence map between individual shapes. The framework consists of iterations where a medial shape representation is deformed into […]

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Evaluation of cartilage and bone degradation in a murine collagen antibody-induced arthritis model.

March 1, 2008

Scand J Immunol

Abstract The purpose of this work was to validate collagen antibody-induced arthritis (CAIA) model in two mice strains (Balb/c and CD-1) using clinical, biochemical, microstructural and histological techniques. We induced arthritis in mice using a cocktail of collagen type II (CII) antibodies followed by an injection with lipopolysaccharide (LPS) in different doses in Balb/c and […]

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Bone turnover and bone collagen maturation in osteoporosis: effects of antiresorptive therapies.

March 1, 2008

Osteoporos Int

Abstract UNLABELLED Bone collagen maturation may be important for anti-fracture efficacy as the reduction in risk is only partly explained by a concomitant increase in BMD during anti-resorptive therapy. Different treatments caused diverse profiles in bone collagen degradation products, which may have implications for bone quality. INTRODUCTION The aim of the present study was to […]

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Osteoclasts secrete non-bone derived signals that induce bone formation.

February 8, 2008

Biochem Biophys Res Commun

Abstract Bone turnover is a highly regulated process, where bone resorption in the normal healthy individual always is followed by bone formation in a manner referred to as coupling. Patients with osteopetrosis caused by defective acidification of the resorption lacuna have severely decreased resorption, in face of normal or even increased bone formation. This suggests […]

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Evaluation of cartilage damage by measuring collagen degradation products in joint extracts in a traumatic model of osteoarthritis.

February 1, 2008

Biomarkers

Abstract The objective of this work was to investigate whether collagen degradation products in protein extract from joints could provide quantitative information on cartilage damage. Osteoarthritis (OA) was surgically induced in rat knee joints. Joints were isolated 7, 14 and 28 days after surgery for protein extraction and histology. C-terminal telopeptide of type III collagen […]

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An update review of cellular mechanisms conferring the indirect and direct effects of estrogen on articular cartilage.

February 1, 2008

Climacteric

Abstract OBJECTIVE To review cellular mechanisms that have been proposed to mediate the indirect and direct effects of estrogen on articular cartilage, and to outline the remaining clinical questions that need to be clarified before utilizing the beneficial effects of estrogen for the prevention of osteoarthritis in early postmenopausal women. DESIGN Summary of original research […]

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Estrogenic uterovaginal effects of oral estetrol in the modified Allen-Doisy test.

January 1, 2008

Climacteric

Abstract OBJECTIVE To evaluate the effect of estetrol (E(4)) on vaginal cornification and uterine wet weight in the ovariectomized rat. METHODS Adult female rats served as experimental animals. Six groups of ovariectomized rats (eight per group) were treated orally once daily for 7 days as follows: vehicle (negative) control; E(4): 0.1, 0.3, 1.0 and 3.0 […]

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Calcitonin: a drug of the past or for the future? Physiologic inhibition of bone resorption while sustaining osteoclast numbers improves bone quality.

January 1, 2008

BioDrugs

Abstract Postmenopausal osteoporosis results from a continuous imbalance between bone resorption and bone formation, favoring bone resorption. An increasing number of treatments for osteoporosis are in development and on the market. A range of differences and similarities are found between these treatment options, and these need to be carefully evaluated before the initiation of treatment. […]

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