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Basement membrane remodeling biomarkers are modulated and reflect treatment response to JAK inhibitors in patients with atopic dermatitis – results from two longitudinal clinical studies.
August 18, 2026
J Invest Dermatol
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Collagen Turnover Is Associated with Disease Severity, Bone Marrow Fibrosis, and the JAK2V617F Variant Allele Frequency in Myeloproliferative Neoplasms.
August 6, 2026
Cancers (Basel)
Abstract : Myeloproliferative neoplasms (MPNs) are blood cancers characterized by elevated blood cell counts, bone marrow fibrosis (BMF), and chronic inflammation, which drives disease progression. BMF results from disrupted collagen turnover in the bone marrow extracellular matrix (ECM), making its reduction or stabilization a key therapeutic goal. Non-invasive biomarkers reflecting collagen turnover could potentially improve […]
Serological biomarkers of extracellular matrix proteins are associated with hidradenitis suppurativa disease severity and treatment response.
August 1, 2026
Skin Health Dis
Abstract Chronic inflammation in hidradenitis suppurativa (HS) disrupts tissue architecture and basement membrane integrity. Biomarkers of extracellular matrix (ECM) and basement membrane degradation (BGM, C7M, C4M) increase with disease severity, while NIC (linker protein degradation) decreases. Elevated baseline C7M is significantly associated with greater improvement in IHS4 following TNF-α inhibitor therapy. ECM remodelling biomarkers reflect […]
Prospective validation of imaging and serum diagnostic biomarkers of steatohepatitis and fibrosis in MASLD: the LITMUS Imaging Study.
August 1, 2026
Nat Med
Abstract There is a need for robust evaluations of noninvasive biomarkers for metabolic dysfunction-associated steatotic liver disease. This prospective multicenter study assessed the diagnostic accuracy of imaging (including liver stiffness measurement (LSM) using magnetic resonance elastography (MRE) and FibroScan (vibration-controlled transient elastography (VCTE)), serum biomarkers (including NIS2+) and composite scores (including Agile 3+ and Agile […]
Crosslinked Fibrin Fragment (X-FIB) as a Biomarker for Endotype Differentiation and Response to Omalizumab Treatment in Chronic Spontaneous Urticaria.
August 1, 2026
Allergy
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A framework and shared vocabulary to identify actionable protein biomarkers and enable optimal precision medicine: Myth-busting with unicorn biomarkers.
July 25, 2026
J Hepatol
Abstract Not all biomarkers are equal, and some arguably should not be classified as biomarkers at all. Despite an explosion in putative biomarker discoveries from high-throughput proteomic technologies, very few advance beyond initial excitement to become validated, clinically actionable tools. Most stall in a biomarker ‘valley of death’, where promising signals fail to meet robust […]
A novel immunoassay for neostatin-7 quantifies basement membrane remodeling and reveals an association with reduced pulmonary function in systemic sclerosis.
July 11, 2026
Sci Rep
Abstract Systemic sclerosis (SSc) is characterized by immune dysregulation, vasculopathy, and excessive extracellular matrix remodeling. Type XVIII collagen in the basement membrane undergoes proteolytic cleavage generating bioactive fragments such as neostatin-7. This study aimed to develop and validate a novel ELISA, NEO7, targeting neostatin-7, an MMP-generated fragment of type XVIII collagen, and to evaluate its […]
Direct visualisation and measurement of lung microstructure reveal insights into extracellular matrix dysregulation in COPD.
July 3, 2026
Respir Res
Abstract BACKGROUND Extracellular matrix (ECM) dysregulation is a key process in the pathology of COPD. However, an inability to characterise ECM remodelling in vivo has limited our understanding of its relationship with functional decline and disease mechanisms. We aimed to quantify in vivo ECM remodelling using probe-based confocal laser endomicroscopy (pCLE) and determine associations with […]
Lung fibroblast activation protein expression is associated with extracellular matrix remodelling in post-acute sequelae of SARS-CoV-2.
July 1, 2026
ERJ Open Res
Abstract https://bit.ly/47rLr0G. Go to full publication
Two-step care pathways for advanced MASLD in primary and hospital care: A multicenter study.
July 1, 2026
Hepatol Commun
Abstract BACKGROUND Early diagnosis of metabolic dysfunction-associated steatotic liver disease (MASLD) fibrosis may prevent liver-related morbidity and mortality. We investigated the effectiveness of multiple 2-step approaches for detecting at-risk advanced MASLD fibrosis, defined as a hierarchical clinical score comprising liver histology and VCTE depending on availability, in primary and hospital outpatient care. METHODS Patients at […]
