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Crosslinked Fibrin Fragment (X-FIB) as a Biomarker for Endotype Differentiation and Response to Omalizumab Treatment in Chronic Spontaneous Urticaria.
August 1, 2026
Allergy
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A framework and shared vocabulary to identify actionable protein biomarkers and enable optimal precision medicine: Myth-busting with unicorn biomarkers.
July 25, 2026
J Hepatol
Abstract Not all biomarkers are equal, and some arguably should not be classified as biomarkers at all. Despite an explosion in putative biomarker discoveries from high-throughput proteomic technologies, very few advance beyond initial excitement to become validated, clinically actionable tools. Most stall in a biomarker ‘valley of death’, where promising signals fail to meet robust […]
A novel immunoassay for neostatin-7 quantifies basement membrane remodeling and reveals an association with reduced pulmonary function in systemic sclerosis.
July 11, 2026
Sci Rep
Abstract Systemic sclerosis (SSc) is characterized by immune dysregulation, vasculopathy, and excessive extracellular matrix remodeling. Type XVIII collagen in the basement membrane undergoes proteolytic cleavage generating bioactive fragments such as neostatin-7. This study aimed to develop and validate a novel ELISA, NEO7, targeting neostatin-7, an MMP-generated fragment of type XVIII collagen, and to evaluate its […]
Direct visualisation and measurement of lung microstructure reveal insights into extracellular matrix dysregulation in COPD.
July 3, 2026
Respir Res
Abstract BACKGROUND Extracellular matrix (ECM) dysregulation is a key process in the pathology of COPD. However, an inability to characterise ECM remodelling in vivo has limited our understanding of its relationship with functional decline and disease mechanisms. We aimed to quantify in vivo ECM remodelling using probe-based confocal laser endomicroscopy (pCLE) and determine associations with […]
Lung fibroblast activation protein expression is associated with extracellular matrix remodelling in post-acute sequelae of SARS-CoV-2.
July 1, 2026
ERJ Open Res
Abstract https://bit.ly/47rLr0G. Go to full publication
Two-step care pathways for advanced MASLD in primary and hospital care: A multicenter study.
July 1, 2026
Hepatol Commun
Abstract BACKGROUND Early diagnosis of metabolic dysfunction-associated steatotic liver disease (MASLD) fibrosis may prevent liver-related morbidity and mortality. We investigated the effectiveness of multiple 2-step approaches for detecting at-risk advanced MASLD fibrosis, defined as a hierarchical clinical score comprising liver histology and VCTE depending on availability, in primary and hospital outpatient care. METHODS Patients at […]
Dual amylin and calcitonin receptor agonists as multifaceted disease-modifying osteoarthritis drugs.
July 1, 2026
Int J Obes (Lond)
Abstract Obesity is a powerful driver in the development and progression of osteoarthritis (OA), contributing to increased mechanical load and metabolic stress, making it a valuable target for treatment. Weight loss is a cornerstone of OA management, improving patients’ quality of life and disease outcomes. This review examines the potential of dual amylin and calcitonin […]
Skeletal muscle proteomics links mitochondrial abundance with peak fat oxidation in physically active young males.
July 1, 2026
J Physiol
Abstract The interindividual variability in peak fat oxidation (PFO) and the intensity at which this occurs (Fat) has been attributed to physiological factors, diet and physical activity; however, few studies have examined the contribution of skeletal muscle characteristics. The present study examined the relationship between PFO, Fat and the skeletal muscle proteome in young, physically […]
Erratum to ‘Hot and cold fibrosis: The role of serum biomarkers to assess immune mechanisms and ECM-cell interactions in human fibrosis’ [J Hepatol 83 (2025) 239-257].
July 1, 2026
J Hepatol
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Fibroblast activity biomarkers are associated with mortality in severe COVID-19: a post-hoc analysis of a phase 2 clinical trial.
June 25, 2026
Respir Res
Abstract BACKGROUND Coronavirus disease 2019 (COVID-19) is a highly contagious respiratory disease characterised by systemic inflammation and lung tissue damage. In injured lungs, fibroblast activity increases in response to tissue insult and has been shown to be prognostic in fibrotic disease. This study investigated whether fibroblast activity is associated with mortality in severe COVID-19. METHOD […]
