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PRO-C11 is associated with disease activity and treatment response in patients with HS
August 28, 2026
The fibroblast activity biomarkers, PRO-C11, quantified in serum, is associated with disease activity and treatment response in patients with hidradenitis suppurativa
Introduction
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease characterized by inflammatory nodules, abscesses and sinus tracts. A key pathological feature is fibrosis, which is caused by accumulation of extracellular matrix (ECM) proteins. Type XI collagen is a minor fibrillar collagen, produced by dermal fibroblasts, and are upregulated in skin fibrosis. This study investigated the relationship between the serological biomarker PRO-C11, quantifying type XI collagen formation, with disease severity and treatment response in HS patients.
Poster
Conclusion
The serum biomarker PRO-C11 was associated with disease severity in patients with HS, and mildly associated with IHS 4 improvement after 3-6 months of anti TNF α treatment. Such biomarker may serve as objective measures of fibrosis and tissue remodeling in HS, help identifying patients at risk of disease progression and the evaluation of treatment response.
