Are you interested in exploring collaboration possibilities?
Enter your information in the form and a representative will contact you shortly.
Collagen Turnover and Fibrogenesis Biomarkers Associate in CKD
August 28, 2026
Collagen Turnover and Fibrogenesis Biomarkers Associate with Kidney Disease Progression in CKD: Data from CRIC and NURTuRE-CKD
Introduction
Fibrosis is a central pathogenic process in CKD progression, and biomarkers reflecting this process may offer prognostic value. Circulating PRO-C6, a pro-fibrotic signaling and tissue formation fragment of type VI collagen, and urinary C3M, an immune cell-mediated degradation fragment of type III collagen, have been previously explored in CKD cohorts, showing prognostic value in patients with different etiologies. The aim of this study was to validate the prognostic potential of PRO-C6 and uC3M in two large well-characterized, prospective, multicenter non-dialysis CKD cohorts.
Poster
Conclusion
Increased circulating PRO-C6 and decreased urinary C3M are independently associated with kidney disease progression and a more rapid decline in eGFR. Increased circulating PRO-C6 is also associated with risk of death. PRO-C6 and C3M provide mechanistic insights into collagen remodeling and fibrogenesis processes during CKD progression that are not captured by conventional markers of kidney function such as eGFR and UACR and kidney injury markers.
