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COL1 fragments induce COL3 formation in 3D PEG hydrogel model with HCF fibroblasts
August 28, 2026
Naturally occurring COL1 fragments induce COL3 formation in 3D PEG hydrogel model with human ventricular cardiac fibroblasts
Introduction
Cardiac fibrosis is a feature of many cardiovascular diseases and is characterized by activation of cardiac fibroblasts. COL3 is one of the ECM proteins affected early during the myocardial fibrotic process and contributes to increased tissue stiffness. Certain COL1 peptide sequence motifs have been observed to stimulate collagen formation or degradation. This project examines the effects of nine of the most abundant naturally occurring urinary COL1 derived peptides on COL3 turnover in a 3D in vitro cardiac fibroblast model.
Poster
Conclusion
Naturally occurring COL1-derived peptides induced a pro fibrotic response in cardiac fibroblasts, resulting in increased COL3 synthesis. These findings suggest that COL1 fragments may contribute to cardiac ECM remodeling and warrant further investigation in fibrosis-related cardiomyopathies.
