Biomarkers

A neo-epitope fragment of type III collagen released during extracellular matrix remodeling, enabling non-invasive quantification of active fibrogenesis and dynamic assessment of fibrosis progression and treatment response. Elecsys automated version: An in vitro diagnostic (IVD)-labelled assay developed in collaboration with Roche Diagnostics. It is intended for clinical use under regulated conditions.

A fragment of the N-terminal propeptide of type XI collagen, enabling non-invasive monitoring of cancer associated fibroblast-driven (CAF) extracellular matrix formation and tumor-associated fibrosis in oncology and fibrotic disorders.

A fragment of the C-terminal domain of type XVI FACIT collagen, enabling non-invasive monitoring of extracellular matrix remodeling and fibrostenotic activity in gastrointestinal disorders such as colorectal cancer and Crohn's disease.

C-terminal of type XXII collagen. FACIT collagen measuring tissue formation, molecular bridging and tissue organization. A fragment of the C-terminal domain of type XXII FACIT collagen, enabling non-invasive monitoring of extracellular matrix organization, molecular bridging and tumor-associated fibrosis across multiple solid tumor types.