Biomarkers

A citrullinated and matrix metalloproteinase-degraded fragment of vimentin, enabling non-invasive monitoring of macrophage-driven inflammation and tissue remodeling across autoimmune and fibrotic diseases.

A neo-epitope fragment of type I collagen generated by MMP activity, quantifying pathological soft tissue destruction and extracellular matrix turnover.

A fragment of the alpha-1 chain of type III collagen generated by human neutrophil elastase (HNE), enabling non-invasive detection of early mucosal inflammation and extracellular matrix remodeling in gastrointestinal disorders.

A neo-epitope fragment of type III collagen generated by cathepsin activity, enabling non-invasive assessment of interstitial matrix degradation and fibrotic remodeling in chronic diseases.

A neo-epitope fragment of type III collagen generated by fibroblast activation protein (FAP) activity, enabling non-invasive assessment of fibroblast-driven extracellular matrix remodeling in fibrotic and oncologic conditions.

A fragment of type VIa1 collagen released by MMP-2. Special beaded filament collagen measuring interstitial ECM destruction. A neo-epitope fragment of type VI collagen generated by matrix metalloproteinase activity, enabling non-invasive assessment of interstitial extracellular matrix remodeling in fibrotic and oncological conditions.

A neo-epitope fragment of the α3 chain of type VI collagen generated by matrix metalloproteinase activity, enabling non-invasive assessment of intestinal extracellular matrix remodeling and disease activity in inflammatory bowel conditions.

A neo-epitope fragment of type VII collagen generated by matrix metalloproteinase activity, enabling non-invasive monitoring of dermal-epidermal junction integrity and tissue remodeling in fibrotic and inflammatory skin disorders.

A neo-epitope fragment of type III collagen released during extracellular matrix remodeling, enabling non-invasive quantification of active fibrogenesis and dynamic assessment of fibrosis progression and treatment response. Elecsys automated version: An in vitro diagnostic (IVD)-labelled assay developed in collaboration with Roche Diagnostics. It is intended for clinical use under regulated conditions.

A fragment of nidogen-1 cleaved by cathepsin S, enabling non-invasive monitoring of basement membrane degradation and tumor microenvironment remodeling in cancer.