Biomarkers

A fragment of elastin cleaved by proteinase 3, enabling non-invasive monitoring of neutrophil-driven extracellular matrix degradation and inflammation in chronic diseases.

N-terminal of EMID1 after cleavage of signal peptide

A fragment of fibronectin generated by matrix metalloproteinase activity, enabling non-invasive monitoring of extracellular matrix remodeling and fibrotic activity in chronic tissue disorders.

A fragment of glial fibrillary acidic protein cleaved by caspase-6, enabling non-invasive monitoring of astrocytic activation and central nervous system injury.

C-terminal end of heat shock protein 47

A neo-epitope fragment of the laminin γ1 chain generated by matrix metalloproteinase activity, enabling non-invasive monitoring of basement membrane remodeling and fibrotic activity in chronic diseases.

A fragment of the LG3 domain of perlecan cleaved by BMP-1, enabling non-invasive monitoring of basement membrane remodeling and fibrotic activity in chronic kidney diseases. In heparin plasma and urine only.

A fragment of the N-terminal midregion of osteocalcin, reflecting bone formation activity.

A fragment of neurocan cleaved by matrix metalloproteinase-2, enabling non-invasive monitoring of extracellular matrix remodeling and blood-brain barrier integrity in neurodegenerative conditions.

A structural axonal protein released upon neuronal damage, serving as a sensitive marker for neurodegeneration and axonal injury.