Biomarkers

A fragment of the C-terminal propeptide of type V fibrillar collagen, enabling non-invasive monitoring of extracellular matrix, myfibroblast and cancer-associated fibroblast (CAFs) formation, indicating fibrotic activity in hepatic and oncological conditions.

A fragment of C-terminal type VIa3 collagen (Endotrophin), enabling non-invasive quantification of fibrogenesis, tissue remodeling and wound healing across chronic diseases.

A citrullinated and matrix metalloproteinase-degraded fragment of vimentin, enabling non-invasive monitoring of macrophage-driven inflammation and tissue remodeling across autoimmune and fibrotic diseases.

Human ADAMTS4 (ADAM with Thrombospondin Type 1 Motif 4)

Human ADAMTS5(A Disintegrin And Metalloproteinase With Thrombospondin 5)

A fragment of aggrecan from IGD1-2 released by ADAMTS-4/5, enabling non-invasive assessment of cartilage degradation and turnover in joint diseases.

A neo-epitope fragment of biglycan generated by MMP-9 and MMP-12 activity, reflecting pericellular matrix degradation and extracellular matrix remodeling.

A fragment of BIGH3 released by MMP-9

A matrix metalloproteinase-generated neo-epitope fragment of type I collagen, enabling non-invasive assessment of extracellular matrix degradation and mortality risk in cardiovascular disease.