C4G

• Quantifies specific fragments of type IV collagen produced by granzyme B activity.
• Reflects T-cell mediated degradation of the basement membrane, indicating immune cell infiltration.
• Provides a non-invasive measure of immune activity within tumor and inflammatory microenvironments.
• Supports monitoring of disease progression and response to immunotherapies.
• Applicable in research on cancers and inflammatory diseases characterized by T-cell involvement.
• Facilitates evaluation of interventions aimed at modulating immune infiltration and extracellular matrix remodeling.
• Complements other biomarkers for a comprehensive assessment of immune-related tissue dynamics.

The C4G biomarker assay measures specific neo-epitope fragments of type IV collagen generated through granzyme B activity, serving as an indicator of T-cell infiltration and basement membrane remodeling in various pathological conditions. This non-invasive assay provides insights into immune-mediated tissue remodeling processes, particularly in cancers and inflammatory diseases where T-cell activity plays a pivotal role. By quantifying collagen degradation products associated with granzyme B activity, the C4G assay aids in monitoring disease progression, evaluating treatment efficacy, and understanding the underlying mechanisms of immune cell infiltration and extracellular matrix turnover. It serves as a valuable tool in both clinical and research settings for assessing the dynamics of immune-related tissue changes.

Nordic Bioscience’s assays and services are research use only products and services and do not qualify for medical or diagnostic purposes.