Biomarkers of collagen turnover and immune cell activity distinguish fibrotic HP from IPF

August 28, 2026

Biomarkers of collagen turnover and immune cell activity distinguish fibrotic hypersensitivity pneumonitis from idiopathic pulmonary fibrosis

Introduction

Idiopathic pulmonary fibrosis (IPF) is the most common cause of pulmonary fibrosis (PF), although it is also present in other interstitial lung diseases (ILDs). This includes hypersensitivity pneumonitis (HP), which is an inflammatory disease caused by an exacerbated response to environmental antigens and can be classified into fibrotic (fHP) or non-fibrotic (non-fHP). Due to the various differences between IPF and fHP, tools to aid the distinction are needed.

This study aimed to assess tissue remodeling and immune cell activity biomarkers as potential tools to distinguish between HP phenotypes and IPF.

Poster

Conclusion

The findings of this study are reflective of the different pathophysiological characteristics underlying each disease and highlights the potential of non-invasive serological biomarkers collagen and immune cell activity as potential tools to distinguish between HP and IPF in the clinic.

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