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CPa9-HNE is Associated with Transmural Healing in Pediatric Crohn’s Disease
March 13, 2026
CPa9-HNE, a biomarker of neutrophil activity is associated with transmural healing in pediatric Crohn’s disease
Introduction
CPa9-HNE, a calprotectin fragment released by human neutrophil estate during NETosis, has been shown to strongly correlate with endoscopic disease activity in adults with inflammatory bowel disease (IBD). CPa9-HNE also serves as an indicator of pharmacodynamic response. This study aimed to investigate the association of CPa9-HNE with endoscopic disease activity and transmural healing in patients with pediatric CD.
Poster
Conclusion
This study showed that CPa9-HNE, a biomarker of neutrophil activity, is associated with mucosal and radiologic mucosal damage in pediatric CD. These findings highlight the potential use of CPa9-HNE as a complementary tool for the endoscopic or radiographic assessment of intestinal mucosal damage/healing and provide an opportunity for further studies in children with CD.
