FAP-Activity Is Associated with Survival Outcomes in Patients with PDAC

November 6, 2024

Fibroblast Activation Protein (FAP) generates a specific type III collagen fragment detectable in serum, which is associated with survival outcomes in patients with PDAC

Introduction

FAP expression is very low in healthy tissues, and highly upregulated in tumors Fibroblast activation protein (FAP) has unique proteolytic activity. The disease specific expression and unique proteolytic activity have made FAP an interesting protein to be utilized for drug targeting purposes. Therefore, it is important to identify the patients with FAP activity.

In this study we aimed to measure FAP activity indirectly through its proteolytic degradation of type III collagen in serum from patients with PDAC and evaluate its prognostic value.

Poster

Conclusion

FAP-activity can be assessed non-invasively through quantification of FAP-cleaved type III collagen and is
associated with survival outcome in patients with PDAC.

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