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A Hallmark of Fibrosis Initiation and Mortality in Alcohol-Related Liver Disease
May 7, 2025
Fibroblast activation assessed by PRO-C3 and PRO-C6 is associated to accumulation of key bile acids – A hallmark of fibrosis initiation and mortality in alcohol-related liver disease
Introduction
Alcohol-related liver disease (ALD) results from persistent liver damage due to excessive alcohol consumption. ALD promotes the disruption of bile acid homeostasis, further contributing for the development of liver fibrosis and disease progression to cirrhosis, and end-stage liver failure.
The use of anti-fibrotic therapy has shown to simultaneously reduce bile accumulation and levels of
fibroblast activity biomarker nordicPRO-C3™. However, the role of bile acids as drivers of fibrogenesis remains unclear. The present work aims to investigate the link between bile accumulation in ALD and fibrosis induction ALD by exploring associations between fibroblast activity biomarkers, bile acids, and clinical outcomes.
Poster
Conclusion
Increased circulating levels of toxic bile acids are associated to fibroblast activation and poor prognosis in ALD. The data presented suggests that bile acids are linked to activation of fibrogenesis and, therefore, may induce the development of liver fibrosis in ALD.
