C3-HNE
A fragment of the alpha-1 chain of type III collagen generated by human neutrophil elastase (HNE), enabling non-invasive detection of early mucosal inflammation and extracellular matrix remodeling in gastrointestinal disorders.
Key features and values
- Quantifies specific fragments of type III collagen produced by neutrophil elastase activity.
- Reflects early-stage mucosal inflammation and extracellular matrix remodeling in the gastrointestinal tract.
- Provides a non-invasive measure for detecting subclinical inflammation in conditions like inflammatory bowel disease.
- Supports monitoring of disease progression and response to anti-inflammatory therapies.
- Facilitates early intervention strategies by identifying inflammation before clinical symptoms manifest.
- Applicable in research on gastrointestinal disorders characterized by neutrophil-driven tissue damage.
- Complements other biomarkers for a comprehensive assessment of intestinal inflammation and tissue remodeling.
Description
The C3-HNE biomarker assay measures specific neo-epitope fragments of type III collagen generated through neutrophil elastase activity, serving as an indicator of early mucosal inflammation and extracellular matrix remodeling in the gastrointestinal tract. This non-invasive assay provides valuable insights into subclinical inflammatory processes, particularly in conditions such as inflammatory bowel disease. By detecting collagen degradation products associated with neutrophil activity, the C3-HNE assay aids in early diagnosis, monitoring disease progression, and evaluating the efficacy of anti-inflammatory treatments. It serves as a valuable tool in both clinical and research settings for understanding the dynamics of intestinal inflammation and tissue remodeling.
Nordic Bioscience’s assays and services are research use only products and services and do not qualify for medical or diagnostic purposes.
