CC16-HNE
A fragment of Clara cell type XVI secretory protein degraded by human neutrophil elastase, enabling non-invasive monitoring of lung-specific neutrophil activity and epithelial injury in respiratory diseases.
Key features and values
- Quantifies CC16 fragments generated by human neutrophil elastase activity.
- Reflects lung-specific neutrophil activity and epithelial damage.
- Provides a non-invasive measure of pulmonary inflammation.
- Supports monitoring of disease progression and response to therapies targeting neutrophil-mediated tissue injury.
- Applicable in research on respiratory diseases characterized by neutrophilic inflammation, such as COPD and IPF.
- Facilitates evaluation of interventions aimed at modulating neutrophil activity.
Description
The CC16-HNE biomarker assay measures specific fragments of Clara cell secretory protein 16 (CC16) generated through degradation by human neutrophil elastase, serving as an indicator of lung-specific neutrophil activity and epithelial injury. This non-invasive assay provides insights into pulmonary inflammation processes, particularly in conditions such as chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF). By quantifying CC16 fragments associated with neutrophil elastase activity, the CC16-HNE assay aids in monitoring disease progression, evaluating treatment efficacy, and understanding the underlying mechanisms of lung inflammation. It serves as a valuable tool in both clinical and research settings for assessing the dynamics of pulmonary inflammation.
Nordic Bioscience’s assays and services are research use only products and services and do not qualify for medical or diagnostic purposes.
