Publications

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Abstract In type 2 diabetes (T2D), kidney fibrosis drives the progression of chronic kidney disease (CKD) and kidney failure. Lower urinary levels of collagen type III degradation (C3M), a biomarker of extracellular matrix (ECM) turnover, have been associated with CKD progression. We investigated the effect of combination therapy with renin-angiotensin system inhibition (RASi) and glucagon-like […]

Abstract Cardiovascular diseases are the leading cause of mortality worldwide, with atherosclerosis and formation of arterial plaques being a major underlying cause. Rupture or erosion of the plaque fibrous cap can result in thrombus formation, arterial occlusion, and a stroke or myocardial infarction. Plaque changes, and endothelial cell barrier leakiness, may result in material leakage, […]

Abstract : Myeloproliferative neoplasms (MPNs) are blood cancers characterized by elevated blood cell counts, bone marrow fibrosis (BMF), and chronic inflammation, which drives disease progression. BMF results from disrupted collagen turnover in the bone marrow extracellular matrix (ECM), making its reduction or stabilization a key therapeutic goal. Non-invasive biomarkers reflecting collagen turnover could potentially improve […]

Abstract Chronic inflammation in hidradenitis suppurativa (HS) disrupts tissue architecture and basement membrane integrity. Biomarkers of extracellular matrix (ECM) and basement membrane degradation (BGM, C7M, C4M) increase with disease severity, while NIC (linker protein degradation) decreases. Elevated baseline C7M is significantly associated with greater improvement in IHS4 following TNF-α inhibitor therapy. ECM remodelling biomarkers reflect […]

Abstract There is a need for robust evaluations of noninvasive biomarkers for metabolic dysfunction-associated steatotic liver disease. This prospective multicenter study assessed the diagnostic accuracy of imaging (including liver stiffness measurement (LSM) using magnetic resonance elastography (MRE) and FibroScan (vibration-controlled transient elastography (VCTE)), serum biomarkers (including NIS2+) and composite scores (including Agile 3+ and Agile […]

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Abstract Not all biomarkers are equal, and some should not be termed biomarkers. Despite an explosion in putative biomarker discoveries from high-throughput proteomic technologies, very few advance beyond initial excitement to become validated, clinically actionable tools. Most stall in a “biomarker valley of death,” where promising signals fail to meet robust technical, scientific, and regulatory […]

Abstract Systemic sclerosis (SSc) is characterized by immune dysregulation, vasculopathy, and excessive extracellular matrix remodeling. Type XVIII collagen in the basement membrane undergoes proteolytic cleavage generating bioactive fragments such as neostatin-7. This study aimed to develop and validate a novel ELISA, NEO7, targeting neostatin-7, an MMP-generated fragment of type XVIII collagen, and to evaluate its […]

Abstract BACKGROUND Extracellular matrix (ECM) dysregulation is a key process in the pathology of COPD. However, an inability to characterise ECM remodelling in vivo has limited our understanding of its relationship with functional decline and disease mechanisms. We aimed to quantify in vivo ECM remodelling using probe-based confocal laser endomicroscopy (pCLE) and determine associations with […]