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PRO-C22 Is Associated with Disease Severity, Activity, and Systemic Inflammation in HS
June 17, 2024
PRO-C22 – A novel serological biomarker of tissue damage is associated with disease severity, disease activity, and systemic inflammation in patients with hidradenitis suppurativa
Introduction
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease that has a substantial diagnostic delay, in part due to diagnostic challenges with lesions mimicking abscesses. Utilizing robust serological biomarkers could aid in earlier diagnosis and better monitoring of disease severity. One such potential biomarker is type XXII collagen, a fibrillar collagen located at the interface between the anagen hair follicle and the dermis in the skin.
In this study we aimed to evaluate a novel serological biomarker reflecting type XXII collagen turnover, in patients with HS to test its association with disease severity, disease activity, and systemic inflammation.
Poster
Conclusion
We developed and evaluated the novel biomarker PRO-C22 reflecting tissue damage, which was associated to disease severity, activity and correlated with systemic inflammation in patients with HS. Such biomarker may be useful in early patient stratification and efficacy of treatment marker.
