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Supramolecularly stabilized diabetes drugs.
May 1, 2020
Nat Biomed Eng
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Combining naproxen and a dual amylin and calcitonin receptor agonist improves pain and structural outcomes in the collagen-induced arthritis rat model.
February 22, 2019
Arthritis Res Ther
Abstract BACKGROUND Pain is a debilitating symptom of rheumatoid arthritis (RA), caused by joint inflammation and cartilage and bone destruction. Nonsteroidal anti-inflammatory drugs (NSAIDs) are used to treat pain and inflammation in RA, but are not disease-modifying and do not prevent joint destruction when administered alone. KBPs (Key Bioscience peptides) are synthetic peptides based on […]
Sprifermin (rhFGF18) enables proliferation of chondrocytes producing a hyaline cartilage matrix.
November 1, 2017
Osteoarthritis Cartilage
Abstract OBJECTIVE Fibroblast growth factor (FGF) 18 has been shown to increase cartilage volume when injected intra-articularly in animal models of osteoarthritis (OA) and in patients with knee OA (during clinical development of the recombinant human FGF18, sprifermin). However, the exact nature of this effect is still unknown. In this study, we aimed to investigate […]