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Increased basement membrane turnover and strongly attenuated interstitial matrix turnover is a key pathological feature of haemophilia.
November 1, 2017
Haemophilia
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Soluble biochemical markers of osteoarthritis: Are we close to using them in clinical practice?
October 1, 2017
Best Pract Res Clin Rheumatol
Abstract Osteoarthritis (OA) is the most common form of arthritis and a major cause of pain and disability. Recent work suggests that the global burden of OA is increasing, and costs associated with treatment are expected to increase dramatically as the aging human population expands. OA is currently diagnosed using radiography, but this technique is […]
Modifiable risk factors promoting neurodegeneration is associated with two novel brain degradation markers measured in serum.
September 1, 2017
Neurochem Int
Abstract There has been limited success with blood-based biomarkers of neurodegeneration. One perceived reason is that blood has no direct contact to the brain. Recently developed blood-based biomarkers of tau-degradation have shown promise as potential tools for peripheral assessment of neurodegeneration; however, factors contributing to the levels of these in blood are poorly understood. Using […]
Low vs. high haemoglobin trigger for transfusion in vascular surgery: protocol for a randomised trial.
September 1, 2017
Acta Anaesthesiol Scand
Abstract BACKGROUND In patients with cardiovascular disease, guidelines for administration of red blood cells (RBC) are mainly based on studies outside the vascular surgical setting with the recommendation to use a haemoglobin (hb) trigger-level lower than by guidelines from The European Society for Vascular Surgery. Restricting RBC transfusion may affect blood O transport with a […]
Cathepsin-S degraded decorin are elevated in fibrotic lung disorders – development and biological validation of a new serum biomarker.
August 9, 2017
BMC Pulm Med
Abstract BACKGROUND Decorin is one of the most abundant proteoglycans of the extracellular matrix and is mainly secreted and deposited in the interstitial matrix by fibroblasts where it plays an important role in collagen turnover and tissue homeostasis. Degradation of decorin might disturb normal tissue homeostasis contributing to extracellular matrix remodeling diseases. Here, we present […]
Excessive matrix metalloprotease-mediated degradation of interstitial tissue (type I collagen) independently predicts short-term survival in an observational study of postmenopausal women diagnosed with cancer.
August 8, 2017
Oncotarget
Abstract Extensive tissue remodeling mediated by matrix metalloproteases (MMPs) is an important part of cancer. The aim of this study was to investigate whether serum biomarkers reflecting MMP-mediated degradation of type I collagen (C1M), type IV collagen (C4M) and citrullinated vimentin (VICM) were predictive of cancer-specific mortality. Between 1999 and 2001, 5855 Danish postmenopausal women […]
Type I and III collagen turnover is increased in axial spondyloarthritis and psoriatic arthritis. Associations with disease activity and diagnostic capacity.
August 1, 2017
Clin Exp Rheumatol
Abstract OBJECTIVES To investigate the turnover of type I and III collagen by neo-epitope markers in patients with axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA). METHODS Patients with PsA (n=101) or axSpA (n=110) and healthy subjects (n=120) were included. Demographic and clinical data were recorded. Markers of type I and III collagen were quantified by […]
Chondrocyte secretome: a source of novel insights and exploratory biomarkers of osteoarthritis.
August 1, 2017
Osteoarthritis Cartilage
Abstract The extracellular matrix (ECM) of articular cartilage is comprised of complex networks of proteins and glycoproteins, all of which are expressed by its resident cell, the chondrocyte. Cartilage is a unique tissue given its complexity and ability to resist repeated load and deformation. The mechanisms by which articular cartilage maintains its integrity throughout our […]
The minor collagens in articular cartilage.
August 1, 2017
Protein Cell
Abstract Articular cartilage is a connective tissue consisting of a specialized extracellular matrix (ECM) that dominates the bulk of its wet and dry weight. Type II collagen and aggrecan are the main ECM proteins in cartilage. However, little attention has been paid to less abundant molecular components, especially minor collagens, including type IV, VI, IX, […]
Cohort Profile: The Prospective Epidemiological Risk Factor (PERF) study.
August 1, 2017
Int J Epidemiol
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