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Type XII Collagen Is Elevated in Patients with Solid Tumors
June 17, 2024
Serum type XII collagen is elevated in patients with solid tumors and is upregulated in cancer associated fibroblasts (CAFs) and normal fibroblasts (NFs) upon TGFb treatment
Introduction
Understanding the tumor microenvironment (TME) and extracellular matrix (ECM) is crucial in cancer research due to their impact on tumor progression. Collagens, major ECM components, regulate cell signaling and behavior, with type XII collagen being particularly vital for ECM organization. This collagen type is often overproduced by cancer-associated fibroblasts (CAFs), and its upregulation has been linked to poor survival outcomes in various cancers. In light of these findings, this study aimed to develop an ELISA for quantifying circulating type XII collagen as a potential cancer biomarker.
Poster
Conclusion
This study unveils a promising avenue for harnessing PRO-C12 as a non-invasive serum biomarker, enabling the quantification of type XII collagen fragments in cancer patients. Further investigations are warranted to explore the potential of PRO-C12 across different cancer types and disease stages, shedding light on its multifaceted role in cancer development.
