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PRO-C11 and PRO-C16 Are Markers of Intestinal Fibrosis – Results from the ImageKids Study
May 18, 2024
PRO-C11 and PRO-C16 are markers of intestinal fibrosis and are associated with MRE-confirmed intestinal strictures – Results from the ImageKids study
Introduction
Intestinal fibrosis and strictures is one of the most challenging complications in patients with
Crohn’s disease (CD). There is an urgent medical need for non-invasive serological biomarkers for intestinal fibrosis, as magnetic resonance enterography (MRE) is not a feasible tool for repeated
monitoring.
In this study we investigated Protein FingerprintAssays (PFA) biomarkers of collagen formation,
PRO-C11 (formation of type XI collagen), and PRO-C16 (formation of type XVI collagen) in serum from pediatric CD (pCD).
Poster
Conclusion
Based on these biomarker data from the ImageKids study, PRO-C11 and PRO-C16 demonstrate potential as important non-invasive biomarkers reflecting intestinal fibrosis and stenosis.
