HFpEF and Extracellular Matrix Dysregulation: Novel Treatment Strategies
Extracellular matrix (ECM) dysregulation is the founding cause of tissue fibrosis, which drives more than 50 pathologies and most chronic diseases. Fibrosis may develop both consequences to either an increase in tissue formation or a decrease in tissue degradation.
Understanding the ECM and the central components of the basement membrane and interstitial ECM will lead to a better understanding of disease mechanisms and novel treatment strategies. This may be a central part of precision medicine strategies to target the right patients.
Speaker line-up and talking points:
Dr. Morten Karsdal
ECM remodeling is the common denominator of all fibro-inflammatory disorders
Collagens have signaling molecules that we need to understand to understand how the ECM affects cells in fibrosis and tissue turnover
Endotrophin and other collagen fragments (Vastatin, Tumstatin and Endostatin) are potential signaling molecules derived from the processing of the collagens in the ECM
Understanding ECM turnover may lead to better insight into disease mechanisms and better biological understanding of individual patients
Dr. Alexander Lynge Reese-Petersen
ECM biomarkers are elevated in chronic pathologies and have prognostic significance for outcome. How can we best use this to guide drug development?
Endotrophin, a collagen hormone in multi-organ diseases
Endotrophin in HFpEF, a potentially treatable high-risk endotype
Use of the tissue turnover profile for patient selection
