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Hot & Cold Fibrosis: Fibro-Inflammatory Biomarkers as Prognostic Tools in ALD
May 7, 2025
Hot & cold fibrosis: fibro-inflammatory biomarkers as prognostic tools in alcohol-related liver disease
Introduction
Alcohol overuse can trigger liver inflammation, which may progress to fibrosis and cirrhosis—stages within the spectrum of alcohol-related liver disease (ALD). The combination of fibrotic and inflammatory processes drives the course of ALD progression and influences the risk of clinical outcomes. The new concept of “hot & cold fibrosis” – defined by the presence (hot) or absence (cold) of immune cells within fibrotic tissues – can help to understand the degree of inflammation associated with liver fibrosis and its impact in ALD progression.
This study aims to investigate how immune cell activity biomarkers can improve the prognostic performance of fibrogenesis biomarkers with established prognostic value for risk stratification in ALD.
Poster
Conclusion
ALD patients at higher risk of clinical outcomes are characterized by increased fibrogenesis and increased
inflammation. Combining biomarkers reflecting different biological processes improved the prognostic performance of individual biomarkers and may aid in selecting personalized treatment based on distinct patient profiles.
