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Osteopetrosis due to lack of acid secretion by osteoclasts is characterized by abolished bone resorption, increased osteoclast numbers, but normal or even increased bone formation. In contrast, osteoclast-poor osteopetrosis appears to have less osteoblasts and reduced bone formation, indicating that...
May 18, 2014
Journal:
Calcif Tissue Int.
Author:
Thudium CS, Moscatelli I, Flores C, Thomsen JS, Brüel A, Gudmann Stæhr N, Hauge EM, Karsdal MA, Richter J, Henriksen K
In the bone remodeling process that takes place throughout the skeleton at bone multicellular units, intercellular communication processes are crucial. The osteoblast lineage has long been known to program osteoclast formation and hence resorption, but the preservation of bone mass and integrity req...
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