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Cohort profile: The Applied Public-Private Research enabling OsteoArthritis Clinical Headway (IMI-APPROACH) study: a 2-year, European, cohort study to describe, validate and predict phenotypes of osteoarthritis using clinical, imaging and biochemical markers.

July 28, 2020

BMJ Open

Abstract PURPOSE The Applied Public-Private Research enabling OsteoArthritis Clinical Headway (APPROACH) consortium intends to prospectively describe in detail, preselected patients with knee osteoarthritis (OA), using conventional and novel clinical, imaging, and biochemical markers, to support OA drug development. PARTICIPANTS APPROACH is a prospective cohort study including 297 patients with tibiofemoral OA, according to the American […]

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Anisotropic diffusion tensor applied to temporal mammograms: an application to breast cancer risk assessment.

January 1, 2010

Annu Int Conf IEEE Eng Med Biol Soc

Abstract Breast density is considered a structural property of a mammogram that can change in various ways explaining different effects of medicinal treatments. The aim of the present work is to provide a framework for obtaining more accurate and sensitive measurements of breast density changes related to specific effects like Hormonal Replacement Therapy (HRT) and […]

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Evaluation of cartilage and bone degradation in a murine collagen antibody-induced arthritis model.

March 1, 2008

Scand J Immunol

Abstract The purpose of this work was to validate collagen antibody-induced arthritis (CAIA) model in two mice strains (Balb/c and CD-1) using clinical, biochemical, microstructural and histological techniques. We induced arthritis in mice using a cocktail of collagen type II (CII) antibodies followed by an injection with lipopolysaccharide (LPS) in different doses in Balb/c and […]

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